上海后花园论坛,上海419论坛,上海品茶网

　　　　　　 CCTV News:On the afternoon of 19th, the State Council Joint Prevention and Control Mechanism held a press conference on the State Council Joint Prevention and Control to introduce the prevention and control of epidemic situation in autumn and winter, and the role played by medical and health workers in fighting the COVID-19 epidemic.

Guo Yanhong, Ombudsman of Medical Administration and Hospital Authority

　　　　　　 Guo Yanhong, Ombudsman of the Medical Administration and Hospital Authority, said that as we all know, medical personnel are an important force in maintaining and promoting people’s health and the main force in promoting the healthy development of medical and health undertakings. The team of doctors is an important part of the medical staff in our country. The CPC Central Committee and the State Council attached great importance to the construction and development of doctors’ team, especially since the 18th National Congress, and adopted a series of effective measures to strengthen the construction of doctors’ team, especially from the aspects of practice management, education and training, financial investment and treatment guarantee, including their rewards and recognition, etc., to strengthen the implementation of work and promote the construction and development of doctors’ team.

　　　　　　 In the construction and development of doctors, remarkable achievements have been made in recent years. First of all, the team of doctors is growing and their ability level is improving. By the end of 2019, the total number of doctors in China reached 3.867 million, an increase of nearly 830,000 compared with 2015, an increase of 27.2%. Among the doctors, bachelor degree or above accounted for 57.4%, an increase of 8 percentage points over 2015. Second, the construction of grassroots doctors has achieved results. In our country, under the guidance of strengthening the grassroots, the construction of doctors in grassroots medical and health institutions has made great progress in recent years. By the end of 2019, the number of doctors in primary health care institutions reached 1.437 million, an increase of 335,000 or 30.4% over 2015. It can be seen that the growth of the number of grassroots doctors is much higher than that of the overall number of doctors. Third, through key support, it has also achieved results in the construction of some weak professional doctors. For example, the number of doctors who are in short supply in pediatrics and psychiatry has increased rapidly in recent years. Doctors who specialize in pediatrics have reached 234,000 in 2019. The construction, ability level, overall structure and layout of the medical team have been steadily improved, and the medical team is moving from high-speed growth to high-quality development. The majority of doctors, together with the majority of medical workers throughout the country, have also made active efforts in providing medical services and improving people’s health.In 2019, the number of medical and health institutions in China reached 8.72 billion, an increase of 4.9% compared with 2018 and 13.4% compared with 2015. In terms of the number of hospitalizations, the number of hospitalizations in medical and health institutions nationwide in 2019 was 266 million, an increase of 4.5% over 2018 and 26.3% over 2015. Judging from the overall growth of medical services, the majority of medical staff have made efforts to improve the overall medical service capacity and quality and promote the health level of the people with professional skills and knowledge.

　　　　　　 We hope that in the next step, all relevant departments in China will make concerted efforts with Qi Xin to build, ensure and develop the team of doctors, so as to benefit all the people with better services and make the team of doctors better contribute to the construction of a healthy China.

Friends, we are really tired of eating melons.Zhang Xiaohan, who is not very reliable, has drawn cartoons again!

This time, she still rushed to the hot search with ambiguous melons. According to her description, a "first-line intellectual actress" who is famous for her urban drama met with a married rich man in a hotel in Hainan, and the rich man also sent the actress high-luxury jewelry worth tens of millions to make her happy …

Regardless of whether this melon is real or not, who will take care of Zhang Xiaohan! Put it directly with a hammer. Stop drawing cartoons! Few of the comic books she drew before have ever come true …

But this netizen is right. People’s curiosity can’t be suppressed. Although we scold Zhang Xiaohan for having no credibility, we still can’t help but look for an "intellectual actress" who can sit in the right place according to the information disclosed.

Some netizens have even started to list the names of qualified actresses, such as Jiang Shuying, Dilraba, Angel, Chen Shu, Song Jia Jr., Sunny, Chen Douling, Wu Jinyan … The appraisal criteria are based on the paparazzi’s phrase "an intellectual actress who is famous for her urban drama".

Among them, Jiang Shuying was listed as the most likely actress by netizens because of too many details.

First of all, Jiang Shuying was really helped by the fire in Nothing But Thirty, and she did play a lot of urban dramas herself. It can be said that when I saw her face, I couldn’t help but think of urban female roles such as Jiang Lai and Wang Manni.

Recently, in Ode to Joy 3, Jiang Shuying still plays an urban white-collar Ye Zhenzhen.

Secondly, Jiang Shuying really went to Hainan recently and had a beautiful photo. In the photo, she has long hair, and the red flower in her ear seems to echo the red flower on the plate in Zhang Xiaohan’s cartoon.

As it happens, Jiang Shuying has also sent several selfies recently, and the jewels in the selfie are particularly eye-catching. Immediately, some netizens said: "Is this the jewelry sent by a wealthy businessman, so it is the show of love?"

However, some netizens immediately clarified that they searched for the same model in Jiang Shuying’s selfie. The bracelets and watches are more expensive, but as an actress in Jiang Shuying’s coffee spot, she can afford them. The necklace is only a niche brand with more than 1,000 pieces, which can’t reach the level of "ten million yuan jewelry" at all.

Jiang Shuying and his studio also denied this speechless rumor., the tone is full of helplessness:"I can be talked about, but I can’t be framed."

Then netizens found out that,The characters of wealthy businessmen and wives in cartoons seem to be very similar to those of Yu Dong, president of Bona Film, and his wife Jin Qiaoqiao., just Jin Qiaoqiao also dyed red hair.

After reading the so-called "evidence" dug up by these netizens, my little sister is completely speechless, and everyone’s ability to learn from the melon is really getting better and better!

Then Jin Qiaoqiao sent a message to respond to this matter:"Rumors stop at the wise! Watch more movies when you have time. "

Later, Jin Qiaoqiao replied to the comments of netizens in the comment area. In the face of the "persuasion" of netizens, my sister said that she was too speechless:"Can you don’t believe those false news that are fabricated and maliciously slandered on the Internet! It’s all fake! Fake! Fake! " "This netizen? Can you have a little brain? "

There are even netizens who call Jin Qiaoqiao the "little three" of Yu Dong, and Jin Qiaoqiao is so angry that he directly returns.: "Who are you talking about? Spread rumors? ! If you don’t get it, you have to take a lawsuit! "

Here, my little sister wants to get a word in,Jin Qiaoqiao clarified the "mistress" as early as 2014.Yu Dong ended his first marriage in 2010, and he and Jin Qiaoqiao only met in 2012, so there is no such thing as "mistress intervening".

Then Jin Qiaoqiao called Zhang Xiaohan, saying that he was also curious about who the three people in his cartoon were, and had to say that Jin Qiaoqiao was somewhat domineering!

Speaking of Jin Qiaoqiao, I believe that everyone’s first impression of her is stillThe charming and charming peacock princess in the 98 edition of The Journey to the WestOk! It is this role that opened her up.The road of "princess professional household".

The second princess in the East China Sea in "Pig Eight Rings in Spring" is also unforgettable, and Jin Qiaoqiao’s delicate, expensive and sweet appearance is really very suitable for playing the princess.

Princess Yuzhen in "The Secret History of Yang Guifei" is even more compassionate. Some netizens even commented that she is very "Guanyin" and has a kind face and a beautiful face.

Because of her extraordinary and recognizable beauty, Jin Qiaoqiao has been quite successful in her career since she graduated from Nortel, which is enough for most students to envy.

It is said that you can’t have both career and peach blossom, but Jin Qiaoqiao is different, and her peach blossom has never been bad.

No, Jin Qiaoqiao’s first love was vigorous enough. He directly held hands with Wu Qihua, the top student of TVB at that time, and officially announced his love affair. If this were put in today, it would be enough to paralyze the server.

At that time, Jin Qiaoqiao was quite pure and beautiful, and her figure was full of pure desire. She was a little girl with a happy face. Look at this dress, it is not out of date now!

Although Jin Qiaoqiao’s mother thinks that Wu Qihua and Jin Qiaoqiao are too different in age and somewhat introverted, she thinks that her daughter will not be happy to live with him.

But when the two were in the thick of love, they couldn’t listen to their parents’ thoughts at all.Wu Qihua even bought a mansion in Shanghai and gave it to Jin Qiaoqiao in the name of "wedding room"It is said that it cost 1.6 million, which was 1.6 million in 2003.

The good times didn’t last long, and the two finally broke up.After all, Wu Qihua is a "playboy" with too much romantic history, and it is really difficult to get results in falling in love with him.

Later, Jin Qiaoqiao has been caught in various scandals, but there has been no "positive fate".

For example, Jin Qiaoqiao, the unspoken rule of Zhang Guoli, was also caught by Deng Jie (although it seems that there is no real hammer at all now, it is just an empty talk and a visual sense) ↓

Some netizens broke the news that they had picked up Jin Qiaoqiao’s mobile phone, saying that Jin Qiaoqiao had received an ambiguous text message from a wealthy businessman who wanted to pay for her dinner date. The text message boasted:"We are not short of money, what price, Miss Jin can say. Whatever you want, we will never make a counter-offer. "

It’s not a scandal, can only say that the entertainment circle at that time was really in hot water …

Jin Qiaoqiao’s second love affair was with Yu Dong, CEO of Bona Film, and they went straight to the marriage hall. Jin Qiaoqiao also gave birth to a son and a daughter for Yu Dong.

I mean, I’m really principled, and I don’t talk much about love, either talking about being popular or talking about movie mogul.

After marrying the president, Jin Qiaoqiao is almost in a state of retirement. She has been working as a full-time mother at home, and her personal social accounts also record anecdotes about her children’s growth, and only occasionally does Yu Dong appear.

Netizens are deeply touched by this.In the past, the goddess became a child nanny after marrying into a rich family, or was she a "widowed baby"!

E-mail flipped through Jin Qiaoqiao’s account and found that there were not many children’s fathers.

Either take your children out with your parents ↓

Or take two dolls to the playground by yourself.

Recently, however, some netizens ran into Jin Qiaoqiao and Yu Dong to take the children to Universal Studios. My son took his mother’s hand and Yu Dong touched his son’s head while listening to the voice. The picture was quite warm. It seems that they were very happy, and netizens were also worried about it.

Although Jin Qiaoqiao has been a stay-at-home housewife for many years, it seems that her life is empty and her career is barren, but at least she is also a serious "Bona boss".

It’s up to her to hold a birthday party, and almost half of the big coffee in the entertainment circle came to celebrate her birthday., Jason Wu, Iola, Jet Li, Tung shing Yee, Xiang Huaqiang, Xiangtai, Zhang Ziyi, Li Xiang, Chiu Man-Cheuk, Pu Cunxin, Fan Ming, Fu Disheng, Ren Jing, Chen Xiao, Huang Yi, Tan Jing, Chen Xuedong … How many female stars can do this in-plane entertainment?

Jin Qiaoqiao had nothing to do but open a hot pot restaurant to kill time. Stars such as Yao Chen, Jerry Lee and Lin Yongjian rushed to call her new store, and her contacts were quite amazing.

Perhaps the family can also be a woman’s career. Although Jin Qiaoqiao has been away from the entertainment circle for many years, who said that it is not a real skill to run the family well? (text/seedling bag)

Mesenchymal Stem Cell (MSC) have unique biological characteristics and therapeutic potential, and are becoming a "new star" in the field of disease research, and the research enthusiasm continues unabated. MSC involves many related researches, such as multiple sclerosis, arthritis, neuropathic pain, intestinal diseases, etc., and is a research hotspot in the field of transplantation and autoimmune diseases.

Statistics on the number of published papers in MSC field from 2014 to 2024, with data from Pubmed.

Mesenchymal stem cells (MSC) are pluripotent stem cells derived from mesoderm with high self-renewal and multi-lineage differentiation potential. They are widely distributed in various tissues of the whole body, with the advantages of easy separation and easy acquisition, and can be differentiated and expanded in vitro.

MSC is an excellent tool for tumor therapy and gene transfer research, functional genomics, drug screening, Qualcomm screening and toxicology. International Association for Cell Therapy (ISCT) defines human MSC as:

Under standard culture conditions, it is adherent growth;

CD105, CD73 and CD90 should be expressed, but CD45, CD34, CD14 or CD11b, CD79α or CD19 and HLA-DR surface markers should not be expressed.

It can differentiate into osteoblasts, chondrocytes and adipocytes in vitro.

Mesenchymal stem cells come from a variety of cells or tissues, such as bone marrow, adipose tissue, peripheral blood, placental tissue, dental pulp and so on. Similarly, MSC can also differentiate into many cell types, such as osteoblasts, chondrocytes, fat cells, muscle cells, nerve cells, stromal cells and so on.

The origin and differentiation of MSC (from references)

It is worth noting that the differentiation potential of mesenchymal stem cells may vary with the source of stem cells, expansion conditions and their culture microenvironment. Three-line differentiation is the focus of MSC culture and amplification. Triple differentiation usually refers to osteogenesis, adipogenesis and chondrogenesis. In order to better understand the triple differentiation of MSC, this paper preliminarily summarizes the general process of triple differentiation of MSC and the identification methods corresponding to some markers.

Osteogenic differentiation

MSC can directionally differentiate into osteoblasts under the stimulation of various cytokines and other physical and chemical environments. Then the osteoblasts further differentiated into osteoblast precursor cells and entered a rapid proliferation period. Osteoblasts synthesize and secrete organic matrix at this stage, forming osteoid (mainly type I collagen), characterized by alkaline phosphatase, which is an early sign of osteoblast differentiation and maturity; Alkaline phosphatase appears blue under the microscope after fixation with blue, while undifferentiated cells have no obvious color.

Mature osteoblasts express ECM calcification-related proteins. Long-term osteogenic induction causes calcium ions to precipitate in the form of calcium salts, forming "bone nodules". Bone nodules can be dyed deep red by alizarin red (alizarin red reacts with calcium to produce a deep red compound), and the strength of osteogenic differentiation can be expressed by the area and depth of the pigment.

Identification of osteogenic differentiation of MSC from different sources

Chondrogenic differentiation

Firstly, MSC gathers into a cluster, and the middle cells in the cluster are transformed into a large and round cell, that is, chondrocyte, through division and differentiation. Chondrocytes produce matrix and fibers (mainly type II collagen), and the expression of type II collagen was observed by immunohistochemistry.

Generally, the differentiation results of chondrocytes were identified by Alyssin Blue. Alisine blue is an alkaline dye, which can combine with nucleic acid in cells to make the nucleus dark blue. At the same time, alisin blue combined with polysaccharides in cartilage matrix, making cartilage cells and matrix light blue.

Identification of chondrogenic differentiation of MSC from different sources

Adipogenic differentiation

There are two stages of adipogenic differentiation of MSC: first, it differentiates into adipose precursor cells, and then it differentiates into adipocytes under the influence of specific stimuli (such as C/EBPs and PPAR-γ).

Cells keep accumulating fat droplets in the cytoplasm and getting bigger. After dyeing with oil red O, it is red under the microscope. Undifferentiated cells have no obvious color.

Identification of chondrogenic differentiation of MSC from different sources

Various factors will affect the differentiation potential. Such as culture environment, growth factors and the existence of other cells, will affect the differentiation process. Specific signal molecules, such as bone morphogenetic protein (BMP) or Wingless related integration site (Wnt), can promote the differentiation of stem cells into bone cells or nerve cells, respectively.

The research on mesenchymal stem cells is so hot that Yiqiao Shenzhou has compiled a detailed MSC operation guide. Protocol is full of dry goods, in addition to the above three-line differentiation identification examples, it also includes how to isolate mesenchymal stem cells, how to subculture and expand them, and how to determine that the expanded cells are mesenchymal stem cells. Welcome to download and learn!

Click on the link above to download the Protocol.

References:

Dragomirka Jovic. A Brief Overview of Global Trends in MSC-Based Cell Therapy. Stem Cell Reviews and Reports, 2022. https://doi.org/10.1007/s12015-022-10369-1

Xing Liang Fan, et al. Mechanisms underlying the protective effects of mesenchymal stem cell-based therapy. Cellular and Molecular Life Sciences, 2020. https://doi.org/10.1007/s00018-020-03454-6

Yu Han, et al. Mesenchymal Stem Cells for Regenerative Medicine. Cells, 2019. doi:10.3390/cells8080886

Tilotta V, et al. Mesenchymal stem cell-derived secretome enhances nucleus pulposus cell metabolism and modulates extracellular matrix gene expression in vitro. Front. Bioeng. Biotechnol. 2023. doi: 10.3389/fbioe.2023.1152207

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　　How do soda music listen to songs together? Soda music is an easy-to-use software for listening to songs. Users can customize the process of listening to songs when using it, and they can also listen to songs with friends. This small series has prepared a detailed tutorial for everyone, hoping to be helpful to your friends.

　　1. First, turn on the soda music, and click "Three Points" in the lower right corner of the song in the recommendation.

　　2. Then click the "Download" button in the upper left corner.

　　3. After downloading, go to "My" and enter the "Download" interface.

　　4. Then find the song to share and click "Three Points" on the right.

　　5. Then select "Share" in the pop-up menu.

　　6. Finally, just choose the object we want to share.

　　The above is the relevant information brought by Xiaobian. Do you think you can help yourself deal with these problems? Like friends, come to IT Encyclopedia to watch more content.

　　10: 01 on May 2, 2024

　　Haikou Meteorological Observatory issued a yellow warning signal for thunderstorm and gale.

　　Yellow warning signal of thunderstorm and gale

　　01

　　Impact period:

　　Affected by convective clouds, thunderstorms and windy weather may occur in the urban areas of our city, Xixiu Town, Changliu Town, Haixiu Town, Shishan Town, Yongxing Town, Chengxi Town, Longqiao Town, dongshan town Town, Longquan Town, Zuntan Town, Xinpo Town, Longtang Town, Yunlong Town, Hongqi Town, Jiuzhou Town, Lingshan Town and Yanfeng Town from 10: 00 to 17: 00, with winds reaching 7-9.

　　02

　　Defense guide:

　　1. The government and relevant departments shall do a good job in wind and lightning protection according to their duties;

　　2. Personnel should stay indoors with good wind resistance, and close doors and windows;

　　3. Outdoor personnel should hide in buildings or cars with lightning protection facilities; Don’t shelter from the rain under trees, poles and tower cranes; Don’t take an umbrella in the open field, and don’t carry farm tools on your shoulders.

　　4. Cut off the dangerous power supply, properly arrange outdoor items that are easily affected by strong winds, and cover building materials;

　　5. Airports, highways, water transportation and other units shall take measures to ensure traffic safety;

　　6. Water operations in relevant waters and passing ships return to Hong Kong to take shelter from the wind and strengthen port facilities.

　　Weather forecast for the next three days in Haikou city

　　Today, from day to night, affected by the shear line, it is cloudy with thunderstorms, with moderate to heavy rain in the local area. The temperature is 25-32℃, the northeast wind turns to southeast wind 3-5, the offshore wind is 5, and the gust is 7-9 during the thunderstorm.

　　On May 3rd (Friday), it was cloudy with thunderstorms in the afternoon, and the temperature was 25-33℃.

　　On May 4th (Saturday), it was cloudy with thunderstorms in the afternoon and the temperature was 25-33℃.

　　The weather in Hainan in the next three days

　　Land weather forecast

　　2 nd day to night

　　In the north, there are thunderstorms in cloudy days, with moderate to heavy rain in the local area. The lowest temperature is 22-24 degrees and the highest temperature is 31-33 degrees.

　　In the middle, there are thunderstorms on cloudy days, with the lowest temperature of 23-25 degrees and the highest temperature of 31-33 degrees.

　　In the east, it is cloudy with thunderstorms on cloudy days, with the lowest temperature of 23-25 degrees and the highest temperature of 31-33 degrees.

　　In the west, it is cloudy with thunderstorms on cloudy days, with the lowest temperature of 24-26 degrees and the highest temperature of 32-34 degrees.

　　In the south, it is cloudy with thunderstorms, with the lowest temperature of 23-25 degrees and the highest temperature of 31-33 degrees.

　　In addition, during the day on May 2, some towns and villages in the northern half of the island will be accompanied by strong convective weather such as thunderstorms and strong winds, short-term heavy precipitation and hail.

　　3 rd day to night

　　It’s cloudy in the north, with local thunderstorms in the afternoon, with the lowest temperature of 25-27 degrees and the highest temperature of 34-36 degrees.

　　It’s cloudy in the middle, with local thunderstorms in the afternoon, with the lowest temperature of 24-26 degrees and the highest temperature of 34-36 degrees.

　　It’s cloudy in the east, with local thunderstorms in the afternoon, with the lowest temperature of 26-28 degrees and the highest temperature of 32-34 degrees.

　　It’s cloudy in the west, with local thunderstorms in the afternoon, with the lowest temperature of 26-28 degrees and the highest temperature of 33-35 degrees.

　　In the south, it is cloudy, with the lowest temperature of 24-26 degrees and the highest temperature of 32-34 degrees.

　　Day to night on the 4th

　　In the north, it is cloudy with thunderstorms and moderate to heavy rain in the local area. The lowest temperature is 25-27 degrees, and the highest temperature is 33-35 degrees.

　　In the middle, it is cloudy with thunderstorms, with the lowest temperature of 24-26 degrees and the highest temperature of 33-35 degrees.

　　In the east, it is cloudy with thunderstorms, with the lowest temperature of 27-29 degrees and the highest temperature of 32-34 degrees.

　　In the west, it is cloudy with thunderstorms, with the lowest temperature of 26-28 degrees and the highest temperature of 34-36 degrees.

　　In the south, it is cloudy with thunderstorms and moderate to heavy rain in the local area. The lowest temperature is 24-26 degrees and the highest temperature is 31-33 degrees.

　　Marine weather forecast

　　Wind forecast in Qiongzhou Strait

　　From 08: 00 on May 2 to 20: 00 on May 2: It is cloudy with thunderstorms, the northeast wind is 5, and the gust is 7-9 during the thunderstorm;

　　From 20: 00 on May 2 to 08: 00 on May 5: It is cloudy with thunderstorms, the southeast wind is level 5, and the gust is level 7-8 during the thunderstorm.

　　Wind forecast in other sea areas

　　2 nd day to night

　　The Beibu Gulf, the western part of the island, is cloudy with thunderstorms, with northeast winds of 5-6 and gusts of 7-9 during thunderstorms; The eastern and southern seas of the island are cloudy with thunderstorms, with southerly winds of 5-6 and gusts of 7-9 during thunderstorms;

　　3 rd day to night

　　Beibu Gulf, the western part of the island, cloudy with thunderstorms, southeast winds of 5-6, and gusts of 7-9 during thunderstorms; The eastern and southern seas of the island are cloudy with thunderstorms, with southerly winds of 5-6 and gusts of 7-9 during thunderstorms;

　　Day to night on the 4th

　　Beibu Gulf, the western part of the island, cloudy with thunderstorms, southeast wind 5-6, gust 7;

　　Safety tips

　　Thunderstorm and windy weather

　　What safety precautions should I pay attention to?

　　Look here!

　　Comprehensive: Hainan Meteorological Observatory, Haikou Meteorology and Haikou Emergency.

　　Yang Shoufa lives in his brother’s house where his family goes out to do business. Because he "feels that he has AIDS", he has never lived in a main house or a partial house, and he has never used his brother’s kitchen.

　　On September 5, 2012, when Yang Shoufa was in the First People’s Hospital of Nanyang City, he inadvertently learned for the first time that he was not an AIDS patient.

　　According to a diagnosis, Yang Shoufa was first diagnosed with HIV on July 15th, 2004, and the diagnosis unit was zhenping county Health and Epidemic Prevention Station (now CDC).

　　Fate played a cruel joke on Yang Shoufa. In June 2004, Yang Shoufa, a 40-year-old farmer from zhenping county, Henan Province, was diagnosed as AIDS by the county CDC. In his words, from then on, "I was ruthlessly thrown into hell and lived in a world that was taboo and far away from the world like plague." Later, his wife divorced him and his children went away with his wife. Zhenping county Health Bureau reported in November 2015 that Yang Shoufa’s HIV antibody screening result was negative. However, half a year later, Yang Shoufa, who was once "born as a death row", has not yet waited for a statement.

　　"What’s your disease?"

　　On May 10, 2016, Yang Shoufa made his experience into a painting with white characters on a red background, and he planned to reflect the situation again. Inkjet said that being misdiagnosed as AIDS, his life "has undergone earth-shaking changes."

　　Yang Shoufa is 53 years old, a native of Silizhuang Village, suburban township, zhenping county, and graduated from primary school. After they got married in 1985, they successively gave birth to a daughter and two men with their wives, and worked on construction sites during farming and slack seasons. Before being misdiagnosed as AIDS, Yang Shoufa also bought a stone crusher, which was later sold because of the bad market. "Why do you make money?" Yang Shoufa recalled that although he was not rich at that time, he was happy.

　　Yang Shoufa recalled that at the end of 2003, Hu Mingdao, a village doctor, informed the health survey that he also went to the north of the village to draw blood. A few months later, Hu Mingdao went to his house and said, "What disease are you?". Because there were many AIDS cases in the village, there were repeated low-grade fever at that time. Yang Shoufa had no doubt, only felt weak all over, "I want to die."

　　Hu Ming Dow said that around 1992, zhenping county sold a lot of "black blood", so many villagers were infected with AIDS; At the end of 2003, when AIDS was screened, there was a policy, which village screened out more than 20, and set up AIDS treatment points, built 5 rooms, and equipped with doctors and nurses.

　　A Diagnostic Table of HIV/AIDS in Rural Areas of Henan Province shows that Yang Shoufa may be infected by "donating blood" and may be infected in "1992". Yang Shoufa recalled that at that time, he was fined for exceeding his life, and his family’s economy was tight. He sold blood once, 50 yuan. "It’s too scary to smoke two big bags at a time, and I dare not sell it again."

　　According to the zhenping county Municipal Health Bureau, Yang Shoufa’s blood sampling date was December 15th, 2003, the initial screening positive date was January 18th, 2004, and the date of diagnosis (note: check the initial screening positive blood samples with different reagents) was June 23rd, 2004. "After the diagnosis, the staff of the county Chinese medicine hospital conducted an epidemiological case investigation and included it in patient management."

　　"Being shunned like a plague"

　　After receiving the notice, Yang Shoufa said that he wanted to commit suicide many times, and his heart was crushed by fear.

　　Previously, Yang Shoufa was in great health, and he could load a car with stones every day. Later, after doing a little work, I felt pain all over. He thinks that he needs nutrition, "I don’t know which day he will live", and he eats meat crazily every day, sometimes he can eat a chicken at one meal.

　　Yang Shoufa didn’t dare to tell his family. At that time, the eldest daughter and eldest son who had dropped out of school followed their wives who were working in Sichuan, and only the second son was studying in Zhenping. Yang Bao (a pseudonym), the 15-year-old eldest son, once went home and accidentally turned to Yang Shoufa’s treatment book and told his mother.

　　There are no secrets in the village. A bunch of people were gossiping. As soon as Yang Shoufa arrived, people walked away. Slowly, Yang Shoufa broke off contacts with relatives and friends, and never participated in weddings and funerals in the village. When I got home, I put the gate on top.

　　"Listening to the child say that her father has AIDS, this disease sounds terrible." Yang Shoufa’s wife, Li Li (a pseudonym), never went back to Zhenping until she sued for divorce in 2010. However, due to Yang’s illness, the zhenping county court did not decide to divorce. In July 2011, Li Li sued for divorce again. Finally, the zhenping county court decided to grant the divorce.

　　Children seldom come back and seldom make phone calls. "I don’t want to contact them either." Asked why, Yang Shoufa was silent.

　　"Can you stay healthy after taking medicine for 10 years?"

　　Taking medicine every day, Yang Shoufa’s health is getting worse and worse.

　　In summer, he wore a thick coat and was "as cold as a sieve". In winter, you can’t hide under the covers, you have to warm yourself in the yard, and your new shoes have been burnt twice. Trembling hands, head covering, buzzing ears, blurred eyes and poor memory.

　　In September 2012, Yang Shoufa was seriously ill and went to the First People’s Hospital of Nanyang City for treatment. "I didn’t dare to say it was AIDS." The next day, he got the test results and couldn’t understand what HIV antibody negative meant. The doctor said, "It means no AIDS."

　　"How is that possible? ！” Yang Shoufa was surprised.

　　This examination also found out that Yang Shoufa suffered from esophagitis, erosive hemorrhagic gastritis, cholecystitis, prostatic hyperplasia and other diseases.

　　Yang Shoufa went to the AIDS treatment point in Shilizhuang Village for consultation. Zhang Qinze, the person in charge, said that he might have been taking anti-HIV drugs and the test results were not accurate. Subsequently, Yang Shoufa stopped taking drugs and went to several hospitals for examination within two years. The results were all negative.

　　"If you are not sick but have taken medicine for 10 years, can your body not collapse?" Yang Shoufa said that seeing a doctor all the year round spent all his savings.

　　In March 2016, in the suburban township government, the staff of zhenping county CDC and County Hospital of Traditional Chinese Medicine had negotiated with Yang Shoufa and his nephew about compensation. "They said that 100,000 yuan could not be paid, so I turned my head and left." Yang Shoufa said. Around May 10th, the village party secretary asked Yang Shoufa if he could compensate 250,000 yuan. If not, he could sue. "My life was ruined, and they only lost 1.2 million yuan!" Yang Shoufa said.

　　Although it has been confirmed that it was misdiagnosed, Yang Shoufa has not come out of the shadow of AIDS, and his life is still very closed.

　　In addition, things have not been solved for a long time, there is no money at home, two sons are not young yet married, and they are in poor health and can’t do anything, which makes Yang Shoufa very worried. In the past two years, he often drinks because of boredom, but he can’t drink well and gets drunk once or twice.

　　Last year, Yang Shoufa drank five bottles of cheap white wine, two of which were exchanged by posting advertisements on tricycles.

　　Yang Shoufa once claimed to be "born as a death row". He said that today, he still can’t see hope, and he lives "people are not like people, ghosts are not like ghosts."

　　■ ups and downs of life

　　● January 2004

　　Yang Shoufa’s initial blood screening showed positive.

　　● June 2004

　　It was diagnosed as AIDS by zhenping county CDC.

　　● July 2011

　　His wife Li Li sued for divorce for the second time, and the court sentenced him to divorce.

　　● September 2012

　　Yang Shoufa went to Nanyang City to check that he did not have AIDS.

　　● November 2015

　　Zhenping county Health Bureau informed Yang Shoufa that the HIV antibody screening result was negative.

　　■ ask questions

　　Why draw blood every year?

　　Didn’t find the misdiagnosis?

　　The staff of the AIDS Prevention Office of zhenping county CDC said that after the diagnosis of AIDS, the annual examination will no longer be HIV screening, but only CD4 (note: the target of HIV attack is immune cell CD4, so its test results play an important role in judging the treatment effect of AIDS), liver function and renal function, so it can’t be checked out.

　　Retained blood in that year

　　Why is it positive?

　　On November 10, 2015, the zhenping county Municipal Health Bureau reported that on July 15, Yang Shoufa asked for HIV antibody testing, and the result was negative, but the blood sample test result of Yang Shoufa retained in 2003 was still positive; The health department of zhenping county attaches great importance to it and will apply to the higher authorities for DNA comparison. On May 12th, 2016, the deputy director of zhenping county CDC said that DNA was not detected because the blood samples were stored for too long. Guo Jiantao, the director, said that because the blood sample is stored in plasma, there is no effective component in it, and DNA cannot be extracted.

　　Photo courtesy of vision china

　　"A bottle contains 30 kinds of nutrients and can be full for 5 hours; Effective weight loss does not rebound; 6 flavors are changed for drinking. " Recently, an anchor sold a meal replacement milkshake called Smeal-NOTO series in the live broadcast room of the e-commerce platform. According to the seller, this meal replacement milkshake is a "body management tool that is popular all over the world". A bottle can provide 200g of protein for oysters, 1,000g of dietary fiber for vegetables, and 20 kinds of vitamins and minerals. The product introduction page also says: a bottle saves you an hour of exercise. On the e-commerce platform, this milkshake sells 39,000 bottles a month.

　　At present, meal replacement has become the new favorite of weight loss circle. meal replacement powder, meal replacement milkshake, meal replacement porridge and other products featuring "low calorie and strong satiety" emerge one after another. Then, can meal replacement products that make dieters rush to lose weight?

　　Eating meal replacement is equivalent to dieting in disguise.

　　"Weight loss with meal replacement is mainly achieved by reducing calorie and nutritional requirements. Improper use will affect health." Zhang Tian, a nutritionist in the Clinical Nutrition Department of Aviation General Hospital of China Medical University, told the Science and Technology Daily reporter that the meal replacement advertised in the market cannot completely replace normal meals. In order to maintain the basic metabolism and normal activities of the human body, a healthy adult woman needs about 1500— 1800 calories, men need 1800— 2,200 calories, safe weight loss is recommended to be reduced by 500— 600 calories, and to ensure that the nutrient ratio is reasonable. "But most meal replacement products do not meet the calorie and nutritional requirements for safe weight loss." Zhang Tian said.

　　Take the Smeal-NOTO series of meal replacement milkshakes in online celebrity as an example. The calorie of a bottle (75g) of meal replacement milkshakes with Ceylon milk tea flavor is 275 calories. The seller said, "One bottle can replace one meal, and three meals a day can be replaced. It is recommended to replace two meals a day, lunch and dinner. It is suggested that you should eat less oil and maintain 6-mdash when you eat a normal diet without meal replacement; 7 points full. "

　　According to the seller’s suggestion, drinking two bottles a day can only consume 550 calories. "This calorie is still very low. Even special obese people need to lose weight in such a low-calorie way under the guidance of a doctor. Eating meal replacement is equivalent to dieting in disguise, and the purpose of losing weight is achieved by increasing the difference between the required calories and the actual calorie intake. " Zhang Tian said that the extremely low-calorie weight loss method is not scientific and difficult to last for a long time. Once it stops, it is easy to cause weight rebound.

　　Long-term consumption is easy to cause malnutrition.

　　The nutrients needed by the human body need to meet a certain proportion. According to the recommendation of China Nutrition Society, lipids should account for 20% of the essential nutrients for human body & mdash; 30%； Protein accounts for 10%— 20%； Carbohydrate accounts for 50%— 65%。

　　As a mixture of various foods, can meal replacement be scientifically matched? The forms of meal replacement food include solid, semi-solid, liquid, etc., usually a mixture of various foods. "Meal replacement foods are often dominated by carbohydrates such as whole grains." Zhang Tian said that long-term consumption of meal replacement can easily lead to unbalanced nutrition and malnutrition.

　　Smeal-NOTO series meal replacement milkshakes claim that each bottle can provide 200 grams of protein (about 22 grams of protein) of raw oysters. However, the ingredient list shows that a 100g meal replacement milkshake only contains 8.6g of protein, so a bottle (75g) can only provide 6.45g of protein. "The protein that a normal human body needs every day is multiplied by 0.8&mdash per kilogram of body weight; 1.2。 For example, 50 kilograms of body weight, the daily protein content is 40-mdash; Between 60 grams. The protein content of this meal replacement is not as high as that of a pack of ordinary pure milk or an egg. No matter how many meals are replaced, the protein quality of each meal cannot meet the needs of the human body. " Zhang Tian said that consumers without nutrition knowledge background are easily confused by publicity.

　　"However, it should be noted that you can’t simply evaluate the quality of a food. For the human body, it is necessary to see whether the food structure can meet the needs of the human body as a whole. " Zhang Tian emphasized that it is ok to use meal replacement with other foods in the diet as long as the nutrition is balanced.

　　Dietary fiber makes people feel full.

　　In addition to low calories, satiety is another label that meal replacement is proud of.

　　Feeling full, in popular terms, means that although I haven’t eaten much, I still feel full. "Meal replacement is mainly based on coarse grains, konjac and other foods with more starch, which is characterized by high dietary fiber content. If you eat too much dietary fiber and you are not easy to get hungry, you can control your desire to eat. " Zhang Tian told the Science and Technology Daily reporter that the satiety of meal replacement is that dietary fiber is at work.

　　Professor Ai Hua, from the Nutrition Research Office of the Institute of Sports Medicine of the Third Hospital of Beijing Medical University, explained that dietary fiber in meal replacement has the function of water absorption and swelling, and it also has satiety effect without being absorbed and utilized by the human body. When dietary fiber is discharged through the intestine, it can also adhere to some fatty things, thus reducing energy intake.

　　Take konjac as an example, its rich glucomannan is very absorbent, so a few solids can form a lot of konjac gum, giving people a strong sense of fullness.

　　However, the dietary fiber provided by meal replacement may not be enough to produce satiety. Take the above-mentioned online celebrity meal replacement milkshake as an example. According to the taste composition table of Ceylon milk tea exposed by netizens, the content of dietary fiber in every 100g of goods is 1.8g, while that in 100g of vegetables generally contains about 3.5g.. Therefore, this bottle of meal replacement milkshake (75g) can’t provide the dietary fiber content of 1,000g vegetables as advertised.

　　In addition, in daily life, there are many coarse grains that can provide dietary fiber, such as corn, sweet potato, oats, brown rice and so on. In contrast, meal replacement food is likely to lose anti-inflammatory, anti-cancer, anti-oxidation and anti-aging substances contained in natural food during production and processing.

　　Zhang Tian also warned that excessive consumption of dietary fiber will affect the digestion and absorption of other foods, leading to unbalanced nutrition and affecting health. "We usually recommend that you eat coarse grains rich in dietary fiber, which should not exceed half of the normal diet. However, the dietary fiber in meal replacement food definitely exceeds this ratio, which is not conducive to the body’s absorption of other nutrients. "

　　For people with metabolic disorders, improper use of meal replacement food may cause health risks. In 2018, in order to lose weight, a citizen of Loudi City, Hunan Province ate only one meal replacement biscuit and some vegetables and fruits for two months, which eventually led to cardiac arrest due to malnutrition.

　　Earlier, the British "Daily Telegraph" published a study by Oxford University. The researchers found that meal replacement can indeed reduce people’s body fat, visceral fat and liver fat, but the myocardial fat has increased. This means that long-term intake of meal replacement has an impact on heart function. Researchers warn that for people with heart disease, dieting may worsen the condition and aggravate heart failure symptoms such as shortness of breath or arrhythmia.

　　Extended reading

　　Past lives of meal replacement.

　　In fact, the birth of meal replacement food has nothing to do with losing weight.

　　The original product of meal replacement series is beverage meal replacement, and its concept can be traced back to the research results of some early physiologists. In the 1940s, some researchers first identified the main nutrients needed for human survival during the period of strict food restriction. In the late 1950s, space flight required the development of highly compact liquid dietary substitutes, and an aqueous mixture was born.

　　At present, beverage meal replacement has occupied an important position in the meal replacement family and has become one of the tools to manage overweight and obesity.

　　On January 1st, 2020, the group standard "Meal Substitute Food" issued by China Nutrition Society was officially implemented. The standard pointed out that meal substitute food is a kind of energy-controlling food specially prepared to meet the nutritional needs of one or two meals for adults during weight control.

　　Zhang Tian said that under the guidance of doctors and professionals, obese and overeating people can choose some meal substitutes with comprehensive nutrition and strong satiety to replace some meals in the overall diet, which can help them lose weight. "But it is not recommended to follow the trend or blindly adopt a very low-calorie and unbalanced weight loss method. Such a low-calorie weight will definitely come down, but then the weight will definitely rebound. If you want to lose weight healthily and not rebound, you must respect science and rebuild a healthy lifestyle. If you are a healthy person with normal weight, you can eat well, and you don’t need to use meal replacement food to manage your weight. "

　　"A bottle of meal replacement milkshake with about 300 calories can be completely replaced by 50 grams of meat +250 grams of vegetables +2 corns /2 slices of bread /50 grams of cereal +5 grams of oil." Zhang Tian said, "People who have no time to cook and eat meal replacement can learn some Aauto Quicker meals. At least the milk, cereal and eggs in breakfast must be guaranteed. "

　　With the gradual expansion of the market scale of meal replacement food, the chaos in the industry is gradually breeding. Some exaggerate publicity to cater to consumers’ psychology of losing weight, some are produced in small workshops but pretend to be big brands, and some even have no products. In addition, the national health literacy is not high enough, which leads many people to fall into the trap of meal replacement.

　　Zhang Tian said that the dietary pattern can be balanced according to the Dietary Guidelines for China Residents, so as to achieve a balanced diet. "In fact, on the basis of a healthy diet, eat a few mouthfuls less every meal and reduce the time of sitting, and the weight will gradually decrease. Losing weight also requires patience. "

01

I haven’t seen CoCo Lee for a long time. Last night, a Weibo made everyone guess.

I wonder what happened to her.

Last night, some people suspected that she was in a bad state and suspected of depression, and some said that she was in a marital situation.

Sister CoCo Lee responded that if it is about CoCo Lee’s marriage, it is best for her sister to explain it herself, but please don’t be too sensitive.

CoCo Lee’s husband is Canadian tycoon Bruce, whose Chinese name is Le Yumin. He used to be the partner of Li Zekai Colby NetLtd, and he has been the executive director of Libiao since 2001 and the president of Libiao (Trade) since 2004.

The difference between them is 17 years old. In 2011, they got married after 8 years of love running.

At that time, the wedding was quite luxurious, and it was said that it cost as much as 120 million yuan. Many big coffees at home and abroad attended the gathering of stars, and the performing guests included Alicia keys, Brother Mars, black eyed peas and so on.

CoCo Lee’s marriage life has always been low-key, and the luxury wedding was also kept secret all the time, but it was unexpected to pass on the marriage change.

Private life is not easy for outsiders to evaluate, but I still hope that coco will be all right.

02

Tom Hiddleston, a "Shake-off" actress, has been exposed to live with Zawe Ashton, who is three years younger.

The two men were exposed to love in September last year, but Shakeson’s friends denied that they were dating.

Now foreign media once again broke the news that the woman had moved to Atlanta to live with Dawson. People familiar with the matter said: "Tom and Zawei have been silent about their relationship, but in recent weeks, she has been accompanying him in the United States. They are very suitable, enjoying the quieter side of life and staying away from the glitz and charm of the entertainment industry. "

I saw that many netizens questioned the woman’s appearance, but the girls are stage performers and quite talented. They are good at writing poems, publishing books and acting.

When people get along together, they may not care about their faces at all.

03

> come on, friend, dog food is coming again.

>Lu Han and Guan Xiaotong again.Show a low-key love, give it.Everyone sent a wave of dog food that was secretly poked.

>In the promotional video recorded by Guan Xiaotong for the new drama, netizens found that the curtains in the video were the same as those in the previous video recorded by Lu Han.

It’s really easy for lovers in love to reveal small details.

Since the announcement of their love affair, the number of public shows of love is not much, but there are always the same clothes and shoes, and the sweet little details in life can’t be hidden.

04

Remember that rich third-generation boyfriend Shi Boxiong who has been circulating since Wu Qianyu and raymond lam broke up?

The eldest grandson of Hong Kong real estate developer Shi Ziqing, the family has tens of billions of assets.

Before Wu Qianyu and raymond lam officially admitted to breaking up, it was always said that it was because the woman had hooked up with the rich three generations.

Shi Boxiong attended the dinner and often played together in private.

However, compared with raymond lam and Zhang Xinyue, their subsequent relationship has been unclear.

Wu Qianyu has publicly dried the flowers that Shi Boxiong gave her. Many netizens ridiculed that she was deliberately exposed and secretly poked to put pressure on Shi Boxiong?

Later, when asked about her boyfriend by the Hong Kong media, she said that she was not ready and wanted to slow down.

Last year, I also sent an ins, which suspected that I was single.

However, in March this year, the two were photographed going out for an outing together, which can be regarded as a rumor that their love affair died.

There is also a Hong Kong media exposure that the two have moved into a new mansion to live together, and the Qianyu BB with a stable relationship is also likely to marry a rich family and make a positive result.

05

At the end of the article, share a group of Zhou Xun magazine blockbusters.

Elegant exotic lady style, can you get it?

Text/peach and plum

Undoubtedly, the ideal is the best among the new power brands at present, and the world of inquiry has become the biggest competitor of the ideal by the bright performance of M7 and M9, and with the exposure of the brand-new world of inquiry M8, the impact of the world of inquiry on the sales volume of the ideal market continues.

Although the new car may not be officially released until Guangzhou Auto Show, the popularity of M8 in the world is very high, and the empowerment of Huawei’s black technology has become the focus of attention in the automotive industry. Moreover, according to the current product camp, it is not difficult to speculate that the pricing of new cars may be in the range of 350,000 to 450,000 yuan, directly targeting the popular and other models in the current market.

Therefore, this model not only bears the heavy responsibility of breaking through the brand in the world, but also has high hopes to become the key to surpassing the ideal of competitors in sales. It is reported that the M8 will be listed at the end of February, and the new car will be delivered in early March. This compact listing rhythm undoubtedly shows the confidence and expectation of the M8 market performance.

According to the exposed pictures, Wen Jie M8 shows a completely different style from and M9 in appearance design. The front face of the new car adopts a brand-new headlight group. Although it retains the family-style design language of the through belt, the details are more exquisite and unique. The design of the closed grille at the front of the car and the possible adjustment of the lamp style indicate that the M8 will bring a refreshing visual experience while maintaining its family characteristics.

As for the interior, the M8 has been innovated and optimized on the basis of inheriting the design of the M9 triple screen, and the right angles on both sides have become rounded corners, which are matched with diamond decorative plates, star ring scatterers, projection giant screens and other elements to create a more luxurious and technological driving atmosphere.

What’s more, the M8 will be equipped with the Rubik’s Cube platform for the first time. This innovative platform not only endows the new car with the unique skill of rear wheel steering, but also indicates the infinite possibilities of the brand in the future product layout.

The Rubik’s Cube platform will be compatible with cars, SUVs, MPVs, pure electric vehicles, extended range, hybrid vehicles and other power forms, laying a solid foundation for the sustainable development of the brand. In the future, with the advent of more models based on the Rubik’s Cube platform, the product matrix of Wenjie brand will be more perfect and the market competitiveness will be significantly improved.

In terms of battery life and charging, the M8 also showed strong competitiveness. The new car will be equipped with the "Whale" 800V high-voltage battery pack. By greatly reducing the number of wire harnesses and the thickness of the battery pack, the fast charging ability of 150 kilometers in 5 minutes is realized.

At the same time, the pure battery life of the M8 is expected to exceed 600 kilometers, and the extended-range version will exceed 1,400 kilometers, which can easily cope with both urban commuting and long-distance travel, showing excellent battery life and fuel economy performance. If this is the case, the M8 can not only balance the problems of endurance anxiety and high oil price pressure, but also attract users’ attention with the blessing of various black technologies.

Write at the end:

At present, with its precise market positioning, innovative design, luxurious interior configuration and strong technical strength of Sanpower, Wenjie M8 can become a group of dark horses in the next new energy vehicle market. In the future market competition, ask whether M8 can successfully surpass competitors such as Ideal with these advantages, realize the leap-forward growth of sales volume, and once again "cripple" the ideal. Everyone who eats melons can look forward to it.

Recently, Xiao Jiu backstage received such a private letter:

"I am 56 years old. I have been diagnosed with hypertension for 6 years, and I have been taking antihypertensive drugs. Yesterday, my old friend shared an article with me and told me that four batches of antihypertensive drugs were recalled because of carcinogens. The antihypertensive drugs I just ate are one of them. What should I do? Should I stop taking the medicine? What should I do if I eat cancer again? "

In fact, it is not the first time that antihypertensive drugs have been recalled because they contain carcinogens. As early as 2018, sartan drugs were recalled. What about this antihypertensive drug recall that fans privately wrote?

01

Reproduced carcinogens, 4 batches of antihypertensive drugs were recalled.

On December 21, 2022, the US Food and Drug Administration (FDA) issued a recall announcement, which stated that Lupin Pharmaceuticals voluntarily recalled four batches of quinapril tablets because nitrosamine impurities, a possible carcinogen, were detected in these drugs, which exceeded the maximum acceptable daily dose stipulated by WHO. The FDA believes that if people are exposed to nitrosamine impurities above the maximum daily intake for a long time, it may increase the risk of cancer.

Quinapril tablet is an angiotensin converting enzyme inhibitor, which is mainly used for the treatment of patients with hypertension to reduce the risk of cardiovascular events caused by hypertension.

Can I continue to take this medicine? According to the company’s announcement, no adverse event report related to this time has been received. And they suggest that patients who take this medicine contact doctors or medical service providers to find out whether to continue taking the medicine or whether to consider other treatment methods before returning the medicine.

In fact, it is not the first time that antihypertensive drugs have been recalled because of nitrosamine impurities:

On March 4th, 2022, Pfizer Canada completely recalled the antihypertensive drugs Accuretic tablets (quinapril hydrochloride and hydrochlorothiazide tablets) in the Canadian market.

On March 21st, 2022, Pfizer voluntarily recalled 11 batches of products in the United States, including 6 batches of Accuretic tablets, 1 batch of quinapril/hydrochlorothiazide tablets and 4 batches of quinapril hydrochloride/hydrochlorothiazide tablets.

On October 24th, 2022, Aurobindo Pharma USA voluntarily recalled two batches of quinapril and hydrochlorothiazide tablets.

The reason for the above three recalls was that the content of nitrosamines containing potential carcinogenic impurities exceeded the prescribed standards. Why do nitrosamine impurities with such high risks often appear in antihypertensive drugs?

Jin Pengfei, deputy director and chief pharmacist of the Pharmacy Department of Beijing Hospital, said that nitrosamine impurities in drugs are related to many reasons, such as process generation, degradation pathway and pollution introduction. In the process of drug synthesis, amine compounds may react with other reagents to produce nitrosamine impurities; Inadvertently using materials contaminated by nitrosamines in the production process of raw materials may also be risky; In addition, some drugs may degrade to produce nitrosamine impurities under special circumstances. He also said that if we want to control the generation of such impurities, we should adopt the strategy of avoiding first and controlling second.

02

Get rid of those rumors about antihypertensive drugs

1. Does hydrochlorothiazide increase the risk of skin cancer?

In 2017, a research article published in the Journal of the American Academy of Dermatology showed that people who use hydrochlorothiazide frequently increase the risk of skin cancer; Coincidentally, an article in the Danish National Demography and Health Registry shows that the use of thiazide diuretic hydrochlorothiazide may increase the risk of skin cancer and lip cancer. So is this really the case?

In this regard, Qin Xiuchuan, chief physician of Beijing anzhen hospital Emergency and Critical Care Center affiliated to Capital Medical University, said that all these so-called studies have great limitations and did not include the main risk factors of skin cancer, such as ultraviolet exposure and skin type. The skin differences between different races are not taken into account, so there is no causal relationship between hydrochlorothiazide and skin cancer. Patients who are taking drugs must not stop taking them without authorization.

2, antihypertensive drugs are dependent, don’t eat?

Many people think that once antihypertensive drugs are taken, they can’t be thrown away. They need to be taken for a lifetime and will be dependent. But in fact, taking antihypertensive drugs is not dependent. Moreover, hypertension itself is a chronic disease that cannot be cured. If you want to control blood pressure in a stable range, you can only take medicine for a long time according to the doctor’s advice to avoid cardiovascular accidents.

3. You don’t need to take medicine without symptoms?

Many people think that no discomfort is a sign of normal blood pressure, so there is no need to continue taking drugs. In fact, this idea is not correct. Many hypertensive patients have no obvious discomfort when their blood pressure rises to nearly 200. Stopping drugs without authorization will lead to excessive blood pressure fluctuation, which is easy to induce cardiovascular accidents.

4. The lower the blood pressure, the better?

Excessive blood pressure drop in a short period of time will easily lead to an increase in the risk of diseases such as cerebral apoplexy. And the lower the blood pressure, the better. For patients with hypertension, what needs to be pursued is to reduce the blood pressure smoothly and control the blood pressure at about 140/90mmHg.

03

Lower blood pressure and put away the summary of Mayo Clinic in America.

Five "depressurization methods"

Mayo Clinic, a non-profit medical institution in the United States, has won the international hospital competition for seven consecutive years. Regarding how to lower blood pressure, Mayo Clinic provides five life suggestions for patients with hypertension:

Eat less salt.

Patients with hypertension should pay attention to eating more fruits and vegetables, grains and low-fat dairy products in their daily diet, and reduce the intake of high-fat and high-cholesterol foods. At the same time, attention should be paid to limiting salt intake, and it is suggested that the daily salt intake should be kept below 5g.

Restrict alcohol and tobacco

Alcohol and tobacco will cause abnormal vasoconstriction after entering the body, and will reduce the efficacy of antihypertensive drugs. It is necessary for hypertensive patients to quit smoking and limit alcohol if they want to control their blood pressure better.

Stick to exercise

It is recommended to maintain at least 150 minutes of moderate-intensity exercise every week, and the time of each exercise is not less than 30 minutes. You can choose aerobic exercise such as walking, jogging, cycling and swimming, and pay attention to long-term exercise.

Lose fat

Obesity is one of the main causes of high blood pressure. It is necessary to lose weight in order to control blood pressure better. Want to lose weight, nothing more than six words-shut up, take your legs, lose weight in a scientific way, and don’t blindly diet.

Learn to decompress

Being in a state of excessive pressure for a long time will lead to sympathetic nerve excitement and easy to cause blood pressure to rise. Pay attention to adjust your emotions in life and don’t let your spirit be too tight.

In short, it is the key for hypertensive patients to take antihypertensive drugs for a long time if they want to control their blood pressure. Hypertensive patients should never stop taking drugs without authorization, and they need to discuss with their attending doctors before making a decision. In addition to taking antihypertensive drugs, we should maintain a healthy lifestyle, eat a balanced diet, eat less salt and exercise more, so that blood pressure will be stable.

References:

[1] Where do the carcinogens that exceed the standard in the "recall door" of Pfizer antihypertensive drugs come from? Phoenix Net Health. 2022-03-27

[2] "Don’t eat antihypertensive drugs! 6 Misunderstandings of Drug Use to Know. Dr. Lilac. 2019-09-05.

[3] "Mayo Clinic in the United States summed up 10" life-lowering methods ",insisting on doing blood pressure can be lowered a little bit". Life Times .2021-04-19

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