上海后花园交友论坛

　　[Autohome new car official picture] Porsche’s first pure electric model (|) will be officially unveiled on September 4. Before that, Porsche also released the interior official picture of the production version of the Porsche Taycan in advance. As Porsche’s first pure electric model, the interior design of the car is largely inherited from the concept car previously released by Porsche – Porsche Mission E, and retains four LCD screens. The overall style is very sci-fi.

"Porsche Taycan Interior"

　　The production version of the Porsche Taycan interior follows the three aspects of "digital, simpler and sustainable", and inherits the traditional Porsche design style. The interior design is inspired by the first generation Porsche 911 unveiled in 1963. The main body adopts a horizontal design language, adhering to the design principle of Porsche "driver-centered" and the instrument panel is higher than the entire center console. The overall design maintains the traditional feeling while adding a lot of sci-fi sense because of the four screens.

"Porsche Taycan Interior"

　　The production version of the Porsche Taycan dashboard features a 16.8-inch curved screen and four display modes (classic mode, map mode, full map mode and pure mode). At the same time, the dashboard also has touch operation areas on both sides, with light controls on the left and buttons for some vehicles on the right. The layout of these control areas is also inspired by the first generation Porsche 911.

"Porsche Taycan Interior"

　　The two screens on the upper part of the center console are 10.9 inches in size (the interactive screen on the passenger side is an optional configuration), and use Porsche’s new interactive interface design, and the whole control logic is more like our commonly used smartphones. The 8.4-inch diagonal screen on the lower part of the center console is mainly responsible for air conditioning control, power and charging status viewing, tablet, etc., with tactile feedback and anti-misoperation functions. It is worth mentioning that the air conditioner trend of the production version of the Porsche Taycan adopts an electronic control design, and users can adjust the air outlet form and direction through the screen.

"Porsche Taycan interior design drawing"

　　It is reported that the future production version of the Porsche Taycan will have a variety of interior color schemes and material schemes, including not only the traditional leather scheme, but also a recyclable and environmentally friendly material scheme that does not use leather at all, while the interior floor mat will use a renewable fiber material called Amanyl.

"Porsche Taycan camouflage test vehicle"

The Porsche Mission E concept car unveiled in 2015

"Porsche Mission E concept car interior"

　　As Porsche’s first pure electric model, the Porsche Taycan has attracted much attention. Before that, we have also interpreted its concept model and some related production model data to a certain extent (want to see more information about the car? Click here: Porsche Mission E technical analysis), and more details about the Porsche Taycan will be fully analyzed in the following technical articles, so stay tuned. (Text/Autohome Shuning)

"Don’t be a broken ear root in the future. Pull out everything in the yard. Experts say it contains carcinogens, and if you eat it, you will get cancer." Uncle Li kept talking to his wife about the harm of broken ears.

"I don’t believe it when I break my ears to clear away heat and detoxify, and it tastes good. Don’t watch those people talk nonsense every day."

"What nonsense? Look at this article. It says that the root of the ear contains aristolochic acid, which is a carcinogen and can’t be eaten. It is also signed by experts!"

"I don’t believe it! I’ve been eating it for decades. Is there a problem? It’s still alive and kicking. "

"Hum, anyway, I won’t eat the roots of broken ears in the future, and you shouldn’t be my share, you are stubborn!" Uncle Li didn’t listen to his wife, so he left without looking back.

Cynanchum auriculatum, also known as Houttuynia cordata Thunb, is not only a vegetable, but also a Chinese herbal medicine. Because of its unique taste and the effect of clearing away heat and toxic materials, it is deeply loved by some people. However, in recent years, there are more and more sayings about "the root of broken ears causes cancer", saying that it contains aristolochic acid carcinogen, which will cause cancer if eaten. Is this statement true or a rumor?

01

Houttuynia cordata Thunb is a harmful grass,

Containing aristolochic acid, is it nephrotoxic and carcinogenic?

Houttuynia cordata Thunb is controversial because it contains aristolochic lactam alkaloids. Then there are many types of alkaloids, including an aristolochic acid component. Because of its strong nephrotoxicity and hepatotoxicity, in 2008, aristolochic acid was officially listed as a class 1 carcinogen by the International Agency for Research on Cancer. Moreover, in 2015, China’s National Pharmacopoeia also deleted three Chinese herbal medicines containing aristolochic acid, namely Aristolochia manshuriensis, Fangji and Aristolochia. Does that mean houttuynia cordata is carcinogenic and can’t be eaten?

Of course not. Aristolochic lactams are divided into many different types. At present, the substances known to be toxic and carcinogenic are aristolochic acid and aristolochic lactam I.. The components in Houttuynia cordata Thunb are aristolochic lactam BII, AII and FII, which are completely different from aristolochic acid I. At present, there is no evidence that these substances in Houttuynia cordata Thunb are toxic or carcinogenic. People who love houttuynia cordata can eat it with confidence.

02

I ate too many vegetables.

Can cause cancer? Don’t be fooled again

1. Eating fresh fungus is easy to induce skin cancer?

The reason for this statement is that there is a light-sensitive substance porphyrin in fresh auricularia auricula, which may cause skin itching, edema and other symptoms after entering the body by sunlight, and even induce skin cancer.

In fact, there are light-sensitive substances in many foods, including celery, and it is not unusual for vegetables to contain this ingredient. The current research shows that the occurrence of porphyria is mainly related to the abnormal metabolism of porphyrin in the body caused by genetic factors, and has little to do with the porphyrin ingested in the diet, so it is safe to eat it every day.

2, bergamot contains carcinogens, can not eat?

It is rumored that the fried bergamot will produce acrylamide, which is considered as a carcinogen, and long-term intake will increase the risk of cancer.

Undeniably, fingered citron will undergo Maillard reaction after being fried at high temperature, and then acrylamide will be generated. However, this reaction is not unique to bergamot, but also widely exists in fried food, baked food and cooking. Therefore, bergamot itself does not contain acrylamide, which is caused by the cooking method. It is recommended to pay attention when cooking. There is also acrylamide, a class 2A carcinogen, which may cause cancer to human beings. At present, there is no clear evidence that people will cause cancer if they eat it. Again, the occurrence of cancer is related to many factors and cannot be simply attributed to a certain food.

3. Does the herbicide contained in rootless bean sprouts cause cancer and teratogenesis?

2,4-Dichlorophenoxyacetic acid plant growth regulator is used in the production of rootless bean sprouts, which is widely used in agriculture. When used in low concentration, it will promote the growth of bean sprouts and inhibit the formation of roots and buds. When used in high concentration, it can really achieve the effect of herbicide, but this concentration will also make bean sprouts unable to grow.

4, raw tomatoes, can lead to gastric cancer or intestinal cancer?

Raw tomatoes contain a lot of alkaloids (solanine), which may cause dizziness, vomiting, diarrhea and other food poisoning symptoms. It is not exaggerated to lead to gastric cancer or intestinal cancer. The occurrence of cancer is related to many factors and will not be directly caused by the intake of a certain food. However, it is still not recommended that you eat raw tomatoes. However, as the maturity of tomatoes increases, the components of Solanum nigrum will be greatly reduced, and this problem will not occur when cooked tomatoes are eaten.

03

Five kinds of food are the culprit of cancer.

According to the danger to human beings, the International Center for Research on Cancer divides the carcinogenic factors into 1 category, 2 category, 2 category, 3 category and 4 category. Among them, class 1 carcinogen means that there is sufficient evidence to prove that it has carcinogenic risk to human body. Through combing, it is found that some carcinogenic factors are hidden in our food, mainly the following five kinds.

Salted fish, pickles, etc.

A large amount of nitrite will be produced in the process of food curing, and nitrite will combine with protein to produce nitrosamines after entering the body, which is a kind of carcinogen and will increase the risk of esophageal cancer, liver cancer, colon cancer and other cancers.

Mildew food

Mildew food is likely to contain aflatoxin, especially foods with high starch content such as peanuts, corn and nuts, which are more likely to be produced after mildew. Aflatoxin is a highly toxic and carcinogenic substance. Intake of 1mg can cause cancer in the body.

barbecue

Carcinogens such as benzopyrene and polycyclic aromatic hydrocarbons may be found in the smoke generated by charcoal burning, the lampblack dripping from meat oil and burnt food when meat is roasted at high temperature. Eating a lot of barbecue for a long time will increase the risk of cancer in the body.

alcohol

Alcohol is a clear carcinogen, and data show that more than 3 million deaths worldwide are related to drinking every year. Smoking and eating a lot of high-fat food while drinking will double the harm to the body. The Lancet magazine directly pointed out that there is no so-called safe amount of drinking, and the best amount of drinking should be 0.

areca

The research published in The Lancet-Oncology pointed out that arecoline in areca catechu has carcinogenic effect, and it was identified as a class 2B carcinogen. Moreover, the fiber in betel nut is very rough, which will continuously damage the oral mucosa when chewing. In the process of repeated injury and repair, the risk of oral cancer will increase significantly.

The occurrence of cancer is related to many factors, and it is unscientific not to blame the culprit on a certain food. Maintaining good living habits and regular physical examination every day is the right way to prevent cancer.

References:

[1] Unbelievable! Are these vegetables "carcinogenic"? Many people don’t know … ".Popular Science China. 2020-07-04.

[2] "Rootless bean sprouts are highly toxic and can cause cancer? No harm to health, no need to worry. The whole people are more serious-Tencent News. 2017-04-14

[3] "Attention! These primary carcinogens are very common in life, but many people are still in the dark … ".Popular Science China.2020-08-02.

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　　Figure ①: Tourists are doing crossword puzzles in the tourist area of Shuidonggou site in Ningxia.

　　Our reporter Yan Limin photo

　　Figure 2: Beijing citizen Zhou Yanbin and his wife are delivering food in the new kitchen.

　　Our reporter He Yongshe

　　Fig. 3: A parent takes his child to visit Ocean Paradise in Nanchang, Jiangxi Province.

　　Xinhua News Agency reporter Zhou Keshe

　　Cartography: Zhang Fangman

　　On the second day of the first month, the "Village Evening" was held in Tunbing Village, Pingyang Town, Xingbin District, Laibin City, Guangxi, which was initiated by entrepreneurs working in other places and attracted hundreds of villagers to watch. The picture shows Zhuang villagers performing on stage.

　　Our reporter Liu Huaxin photo

　　Residents of Paizilou in Beijing:

　　"Cooking in your own kitchen is comfortable."

　　Our reporter He Yong

　　In Houguaibang Hutong, Dongcheng District, Beijing, an old "Paizilou" has taken on a new look after three months’ renovation, with Spring Festival couplets, blessings and window grilles on the doors of every household, which is a jubilant scene.

　　Zhou Yanbin, 68, is busy in the kitchen wearing an apron. The reporter saw that in a space of about 6 square meters, there are all kinds of cooking stoves, range hoods and lockers, and all kinds of ingredients are on the table, just waiting for the pot. "Cooking in your own kitchen is comfortable!" Zhou Yanbin said happily.

　　"Last year, you see, this building is not like this at all. It is not easy to really belong to your own kitchen! " Zhou Yanbin’s wife, Zhao Xijin, told reporters, "This is an old building built in the 1950s. It originally belonged to the office of the unit. Later, the unit distributed the rooms on the third and fourth floors of the building to employees as dormitories. Each floor has a public bathroom and kitchen, and all residents in the floor share a water meter."

　　For decades, residents have "enclosed" public toilets and kitchens for their own convenience. The building is full of small compartments separated by residents’ private construction, and the lock on it becomes a private kitchen. Opaque glass blocks are used in public toilets, and a water heater becomes a private bathroom. Sewers are often blocked, and private wires are pulled on the roof of the corridor, which poses a serious safety hazard.

　　Zhou Yanbin introduced that last year, Chaoxi community joined forces with tap water, power supply and other units to transform the problems of water use and circuit aging in the building. The biggest change is that every household has its own kitchen and bathroom, and the community has re-divided the original public space of about 50 square meters on the floor, with each household being about 7 square meters.

　　"Does the cost of renovation need to be borne by residents?" The reporter asked questions. Zhou Yanbin said excitedly, "This renovation not only confiscated a penny from us, but also lasted for three months. During this time, we also paid rent subsidies!"

　　Humar Khan, Qitai County, Xinjiang:

　　"The road is repaired and the county seat is nearby."

　　Our reporter altak.

　　"It didn’t take you long to come here, did it? This road has changed a lot! " During the Spring Festival holiday, the reporter visited relatives in Kuangou Village, Qitai County, Xinjiang, and chatted with relatives. When it comes to the road from the county seat to the village, Uncle Humar Khan’s tone is full of excitement. "In the past, it took us three or four hours to get back to the village from the county!" He said that although Kuangou Village is only 50 kilometers away from the county seat, the road conditions are complicated, and it is impossible to pass through a river when there is a flood. There is also a dangerous mountain road, which is narrow and bumpy and can only pass in one direction.

　　Now, the dirt roads have become asphalt roads, the bridges across the river have been strengthened, the rugged mountain roads have been widened, and protective fences have been installed on the roadside. "Now into the county seat, it will arrive in less than an hour. What do you mean?" He smiled and said, "The road is repaired, and the county seat is nearby!"

　　"Why don’t you say, we don’t take the bus now?" My second aunt also joined us in the conversation. In the past, villagers could only travel by a bus. They got up before dawn to wait in line for the bus. If they missed it, they had to wait for the next day.

　　Nowadays, the number of buses entering the village has increased to three times a day, but some villagers have stopped taking buses. There are all kinds of cars in the village. If you want to go to town, you can take a lift and leave.

　　"The road has been repaired, and the days are booming. What a change!" The second uncle said excitedly.

　　Changyin, Pizhou City, Jiangsu Province:

　　"The most important thing is to do things in a down-to-earth manner"

　　Our reporter Gong Xiangjuan

　　Going home for the New Year, the reunion of middle school classmates is a must. The enthusiastic convener of this year’s gathering of graduates from Yanjia Middle School in Pizhou, Jiangsu Province is still the old monitor Wang Lu, who started his own company to produce asphalt mixture after he retired from the army.

　　Talking about business, Wang Lu looked relaxed. "Last year was better than the year before!" Wang Lu said that now that the policy is strictly controlled, enterprises that meet the environmental protection standards will not suffer losses. His company is now in place with environmental protection measures, and its business scale will double in 2017!

　　While speaking, the thinnest classmate sitting opposite often interjected, "It’s all done in this way. When I graduated from college and just went to work in a decoration company, I was completely blind. Later, I was not only able to design independently, but also undertook the later construction. Now, the business grows every year! "

　　"Tell me about your unique skills?" The students booed and asked. "There is no trick, the main reason is that I am more practical," Chang Yin said seriously. "New customers are introduced by old customers and passed on from mouth to mouth. Let’s young people, just starting, it is most important to do things in a down-to-earth manner! "

　　The sound of blessing and clinking glasses are intertwined, and everyone’s eyes are shining with happiness.

Scan the code to watch "Reflecting China to the World — — Hundreds of movies are broadcast live for the New Year. "

Special feature of 1905 film network Yinhu exulted in He Xinchun and met Beijing for the Winter Olympics. The pace of the Spring Festival in the Year of the Tiger is approaching, and the movie Spring Festival file is also ready to go. With the box office record set by the Spring Festival file year after year, "watching movies during the Spring Festival" has increasingly become an important source of new people’s customs and happiness in Chinese. This year’s Spring Festival coincides with the Winter Olympics. The collision between traditional culture and the Olympic spirit has added a different charm to Renyin Spring Festival.

To welcome the Winter Olympics and celebrate the Spring Festival, the 1905 movie network client will launch "Reflecting China to the World — — Hundreds of movies are broadcast live for the New Year. Since New Year’s Eve (January 31), more than 100 high-quality domestic films have been selected and broadcast continuously for 7 days and 168 hours. With the annual theme activities, the audience will be accompanied by light and shadow to spend the gathering time. With the national business card of China Film, the real, three-dimensional and comprehensive China will be shown to the world, the story of China will be told to the world, the splendid mountains and rivers of China will be displayed, and the concept of a community of human destiny will be conveyed through movies.

Click to watch:"Reflect China to the world — — One hundred movies live for the New Year "propaganda film.

The seven-day live broadcast will focus on seven major themes: Happy Night on New Year’s Eve, Celebrating the Spring Festival with the Family and the Communist Party of China, Hip-hop Playing the Year Beast, Love Like Mountains and Seas, Accompanying with the New Year, Light and Shadow Olympics, The God of Wealth Welcomes Home, and Struggle for Life.

The list of 100 films covers comedy, action, love and sports. There are both classic old films and new movies, which together provide a feast for the audience in the Spring Festival movies. The movie channel and the anchor group of the 1905 movie network are assembled to accompany you throughout the New Year. We don’t close for the Spring Festival in the Year of the Tiger!

Home country celebrates the Spring Festival.

Hundreds of excellent films warm the New Year and show beautiful mountains and rivers.

As the Spring Festival is approaching, the smoke from the northeast farmers rises, and the fragrance of rice wine can’t be hidden in Jiangxi alleys. The West Lake vinegar fish in Hangzhou restaurants is full of fragrance, and Tibetan families in Xining, Qinghai also sing festive songs … The annual flavor of Chinese can’t be separated from family reunion, and even less the hometown flavor of fireworks.

In the live broadcast of New Year’s Eve, we will also aim at the New Year’s Eve tables all over the country and all over the world, and soothe the homesickness of the wanderers with the "flavor of the year" of China on the tip of the tongue. There are also large-scale happy screenings during the Spring Festival. Whether you are on the journey home, the reunion dinner table or the reunion with your family in the hard-working city, there is always a warmth and light and shadow.

"Home is the smallest country, and there are thousands of countries." The reunion and happiness of hundreds of millions of families have gathered into the Vientiane renewal of the land of China. On the first day of New Year’s Day, the acclaimed and popular new mainstream masterpieces will take you to visit the beautiful mountains and rivers of the motherland and feel the happy life of thousands of families and the ever-changing land of China.

The special guest "National Treasure Panda" will also make a surprise appearance in the live broadcast room. On New Year’s Eve, we will continue to broadcast the gestation process of the first tiger baby in the Year of the Tiger. Tiger treasure and national treasure "Shuang Bao Shousui" send you the most "energetic" blessing.

Hip-hop is full of fun to play the New Year’s beast, peach blossoms are full of happiness, and the god of wealth is greeted with joy. These traditional new year customs add a strong flavor to the Spring Festival, and we will also customize special theme activities in the live broadcast room to accompany you to laugh and celebrate the New Year.

On the second day of New Year’s Day, the classic action comedy films of four filmmakers will be shown in a concentrated way. There is also the Golden Rooster Award online celebrity poster "Staring at the Rooster", in which the author draws a tiger on the spot, and the "lion boy" restores "the lion king strives for hegemony", which is appropriate in movement and excitement.

On the third day of the lunar new year, love is like mountains and seas, and the new year will follow. Love masterpieces such as "Ex 3" are sweet and continuous broadcast, and the anchor punches in the "dating resort" to take you to talk about a vigorous "love" with the movie.

On the fifth day of the first month, the God of Wealth is welcomed, and lucky strike is blessed. From the beginning to the end, "winners in life" all over the country will use movies to teach you how to make money wisely and attack life.

Light and shadow Olympic sentiment

"Together to the Future" Voice of sing the chinese, sports light and shadow help the Olympics

The year of China meets the Winter Olympics, and the national events meet the world competitions, adding even more joy to the Spring Festival in the Year of the Tiger. On the first day of New Year’s Day, more than 100 musicians and filmmakers performed together. The slogan of the Beijing 2022 Winter Olympics and Paralympic Games, the short music film "Together for the Future", will be launched on the whole network. On the first day of the Year of the Tiger, it will "together for the future" to the voice of sing the chinese in the world!

On the fourth day of the Lunar New Year, the 2022 Beijing Winter Olympics was grandly opened, which coincided with the first solar term of the Year of the Tiger — — Beginning of spring means that spring returns to the earth and everything is renewed. We will also relive the beauty of sports in light and shadow, feel the filmmakers’ Olympic feelings, and cheer for China athletes who are struggling on the field.

It is still remembered that 14 years ago, at the opening ceremony of the 2008 Beijing Olympic Games, the director wowed the world with a magnificent feast of light and shadow, showing the splendid civilization inherited for thousands of years and the enthusiasm and tolerance of modern China. Now, as the first city to host the Olympic Games in history, Beijing is ready to go, and Zhang Yimou will set off again.

In the live broadcast room on the fourth day of the first month, we will take you back to the representative works of Zhang Yimou’s 35-year directorial career, from the shocking scenes of China Red in the movie to the black and white splash of ink and the northern scenery. While feeling the unique color aesthetics and artistic style of Zhang Yimou, we will jointly look forward to the gorgeous bloom of the opening ceremony of the Winter Olympics. The director will also be an exclusive guest in the live broadcast room to talk about the cooperation story with his father Zhang Yimou and share the Olympic complex.

The charm of competitive sports lies not only in standing at the peak forever, but also in perseverance after every fall and never giving up when frustrated. Inject the spirit of sports into ordinary life, and small people can create extraordinary things. On the sixth day of Lunar New Year’s Eve, I will take you to witness the "miracle" of ordinary people’s counterattack and flash their lives. In order to save energy for construction, the Year of the Tiger will surely be powerful.

To the world, reflecting China.

Give full play to the advantages of national mainstream film platform

From 340 million in 2011 to 7.172 billion in 2021, through ten years’ hard work, Spring Festival has become the most important "first slot" in China film market. Behind the geometric growth of box office figures, it reflects the rapid development of film industry, the continuous improvement of people’s cultural consumption level and the all-round take-off of social economy.

In 2021, eight of the top 10 Chinese films at the box office are domestic films, and domestic realistic movies that focus on reality and are close to life are increasingly welcomed by the audience. This time, "Reflecting China to the World — — The film list of the "One Hundred Movies Live Over the New Year" activity is also starting from this, gathering domestic film masterpieces of various types, themes and styles, giving back to the audience’s enthusiasm for watching movies and demonstrating China’s cultural self-confidence.

Talking about the original intention of planning this live broadcast, yeyu, the editor-in-chief of the film channel, said that the film channel, as a national mainstream film platform, gives full play to the advantages of more than 10,000 high-quality film libraries, opens up channels of TV, Internet and mobile terminals, and works together to spread excellent domestic films, making "watching movies during the Spring Festival" a new folk custom and telling the story of China to the world.

Wei Li, chairman of 1905 Film Network, also said, "Reflect China to the world — — The "One Hundred Movies Live Over the New Year" campaign uses light and shadow to convey the beauty of movies, life and home country to users through the live broadcast of 7 days and 168 hours, and also echoes the theme of "A Moment of Beauty in Movies" in 1905 Film Network, bringing warmth and touch to users when the whole country celebrates and the whole family is happy.

Tiger jumps in the Spring Festival, and light and shadow follow. In the next 7 days, please lock the 1905 movie network APP. In the Spring Festival of the Year of the Tiger, we don’t close. We will spend the "beautiful" moment with you in the Spring Festival with movies and enjoy the future together!

The treatment of blank wall is an important link in house decoration. Proper treatment can lay a good foundation for the subsequent decoration work, and also enable the wall to achieve the ideal decorative effect. The following is a detailed introduction to the treatment methods and related matters needing attention of the blank wall for you.

The first is grass-roots treatment. There are usually impurities such as dust, oil pollution and loose objects on the surface of the blank wall, which need to be cleaned comprehensively first. You can use brooms, vacuum cleaners and other tools to remove dust. For the parts with serious oil pollution, you can use cleaning agents to wipe them. If there are cracks, holes and other defects in the wall surface, it needs to be filled with gypsum or special repair materials. Small cracks can be directly repaired with putty, and larger cracks need to be embedded with bandages or mesh cloth before filling them to prevent cracks from cracking again.

The next step is wall leveling. Uneven wall will affect the subsequent decoration effect, so leveling is needed. Commonly used leveling materials are cement mortar and putty powder. If the deviation of wall flatness is large, coarse leveling can be carried out with cement mortar first, and fine leveling can be carried out with putty powder after drying. When daubing putty, it is generally necessary to daub it for 2-3 times, and the interval between each time should be determined according to the weather and material description, usually 1-2 days. The thickness of each application should not be too thick to avoid cracking.

Then it is sanded. After the putty is dried, it is necessary to polish the wall surface with sandpaper to make the wall surface smoother and flatter. The mesh number of sandpaper should be selected according to the flatness and grinding stage of the wall. Generally, rough sandpaper is used for preliminary grinding first, and then fine sandpaper is used for fine grinding. Pay even attention when polishing to avoid polishing marks.

Finally, the wall decoration. After the previous treatment, the wall can be decorated, such as painting latex paint and pasting wallpaper. When painting latex paint, we should pay attention to selecting products with good quality and high environmental protection performance, and make deployment and construction according to the requirements of the manual. When pasting wallpaper, pay attention to the splicing and alignment of wallpaper to avoid problems such as empty drum and edge warping.

In the process of dealing with the blank wall, there are also some matters needing attention. When treating at the grass-roots level, it is necessary to ensure that the wall is completely dry before the next step of construction, otherwise it will affect the adhesion and drying speed of subsequent materials, and even lead to problems such as moldy and falling off the wall. In the process of wall leveling, it is necessary to control the proportion and coating thickness of cement mortar and putty powder to avoid cracking and hollowing. When sanding, you should pay attention to protective measures, such as wearing masks and gloves, so as to avoid inhaling dust and causing harm to your body. In the stage of wall decoration, we should pay attention to the temperature and humidity of the construction environment, and avoid the construction in the environment of high temperature, high humidity or low temperature, so as not to affect the decoration effect.

The following is a simple comparison table for you to understand the main points of different processing stages:

Through the above methods and precautions, I believe you can handle the blank wall to achieve the ideal effect and add a beauty and comfort to your home environment.

[Disclaimer] This article only represents the author’s own views and has nothing to do with Hexun. Hexun.com is neutral about the statements and opinions in this article, and does not provide any express or implied guarantee for the accuracy, reliability or completeness of the contents. Readers are requested for reference only, and please take full responsibility. Email: news_center@staff.hexun.com.

　　Diplomacy is no small matter. Some seemingly casual details often reveal meaningful signals.

　　Just now, in the Oval Office, US President Trump met with Liu He, Vice Premier of the People’s Republic of China, the special envoy of the Supreme Leader. The meeting lasted 40 minutes. According to the subsequent release of Xinhua News Agency, Trump also emphasized to Liu He:I highly cherish the good working relationship and personal friendship with the Chairman of the Supreme Leader.

　　Trump, the chief correspondent of Twitter in the White House, also quickly posted relevant information on Twitter, saying that he had talked with Liu He about trade issues. In the photo, Trump with a red tie stood on the right and Liu He with a blue tie stood on the left. They shook hands and smiled.

　　Sino-US trade negotiations are still going on, but during the talks, Trump suddenly met Liu He at the White House, and the information conveyed should be quite rich, at least these three clear signals:

　　1. There have been subtle changes in the attitude of the United States.

　　The last time Liu He visited Washington, not long ago, US Treasury Secretary Mnuchin led a delegation to Beijing for consultations, but the top leaders of the two countries did not come forward to meet. But this time, Trump not only met with Liu He, but also smiled brilliantly.In addition to Mnuchin and other US ministers, accompanied by US Vice President Burns. The President and Vice President of the United States met with Liu He, a vice-national.It can also be seen that the US attaches great importance to the China delegation.

　　In addition, in the Xinhua News Agency report, the first thing Trump said to Liu He was,"It is very important for the United States and China to maintain good cooperative relations in the economic and trade field." Please note that this is "very important".Since it is very important, the United States should also be soberly aware that once it derails, it will shake the earth.

　　Second, China and the United States have differences, but both want to solve them properly.

　　According to Xinhua News Agency, Trump said to Liu He:"I hope that the economic teams of the two countries will work together to actively solve the problems existing in the economic and trade relations between the two sides."Liu Heze said:"China is willing to work with the United States to properly handle and solve economic and trade issues of mutual concern on the basis of equality and mutual benefit, and ensure that economic and trade cooperation will continue to be the ballast stone and propeller of Sino-US relations."

　　There are indeed big differences between the two sides. What should we do? Please note that the Chinese word is "properly handled" and Trump’s word is "actively resolved". There are subtle differences in words, but their attitudes are basically the same. In other words, both sides believe that these differences should not be allowed to affect the relations between the two countries, which creates better conditions for the final success of the negotiations. Of course, China also has principles: on the basis of equality and mutual benefit.

　　Third, there is huge space for future cooperation between China and the United States.

　　During the meeting, Trump also said this to Liu He:The United States and China should focus on strengthening trade and investment cooperation in the fields of energy and manufacturing, expanding agricultural products trade and market access, and strengthening cooperation in intellectual property protection to bring more practical benefits to the two peoples.

　　This should be the key cooperation area listed by the United States.These are all businesses, and China really may not suffer.It must be noted that in these areas, the United States has great advantages, and China’s appropriate increase in some imports is conducive to meeting people’s needs for a better life and is more conducive to the formation of a domestic competitive market. For example, energy is the blood of the economy, and China needs to import a lot of energy to develop; China needs blue sky, and natural gas is in short supply. In this regard, the United States can make more contributions. Of course, China’s energy exploitation technology should also catch up quickly.

　　In the previous article, bullpiano said,The trade war between China and the United States seems to be on the verge of exploding, but from the perspective of the ultimate win-win situation of harmony and wealth, it is just a fierce bargaining before larger-scale cooperation.

　　For the delegation of China, this is really a heavy responsibility. We must defend China’s legitimate rights and core interests, and we must defend the multilateral free trade system and global free trade.

　　Because in the process of consultation, there is no lack of wild speculations. Some western media also broadcast the so-called news that China made substantial concessions and accepted the US deficit reduction of $200 billion.

　　However, people familiar with the matter made it clear that this is false and purely misunderstood.

　　According to the interpretation of relevant people:

　　1. It is absolutely impossible for the Chinese team to negotiate under the conditions set by the US. This point has long been made public in the last round of Beijing consultations.

　　2. Some of China’s concerns, such as the ZTE incident, have been hinted by the relevant US parties in Twitter a few days ago; In addition, both sides have made progress in expanding the export of chips and high-tech products to China in the United States and relaxing energy exports to China. The final result of this transaction is worth looking forward to. Some people worry that China will make unilateral concessions, which is unnecessary.

　　3. The final result of the negotiations will come out after a while, and the so-called rumors of China’s concessions will be broken by then!

　　However, this is still a bitter battle.

　　According to informed sources,Just a few hours before Trump met with Liu He, the two sides still refused to give in to each other on the focus issue, and the negotiations were once deadlocked.Trump’s sudden meeting and the smiling handshake between the two sides undoubtedly put an end to the hard negotiation of this day.

　　Negotiations will continue and the game is still going on. Strive for the best results and prepare for the worst.Tomorrow is a crucial day!(Author Niu Qinqin)

"Don’t imprison curiosity because of grades. Every course and every topic is an opportunity to explore the mysteries of nature and human beings." Lin Jianhua, president of Peking University, delivered a speech on the topic of "Listening to the voice of learning" at the ceremony on September 8th.

On the same day, more than 3,000 freshmen from 2017 Peking University gathered in Peking University Qiu Deba Gymnasium for the opening ceremony. Zhao Lanxin, who won the first place in the Chinese Women’s Mathematical Olympiad, spoke as a freshman representative. The "mathematical genius" said that writing is also her inner passion. She used "Why don’t teenagers dream of catching stars?"? Dare to shoot the jade scale with a mulberry bow. Don’t be too smart today, and invite him to see the sea level tomorrow. " Poems to express their outlook on college life.

Before the ceremony, Professor Hao Ping, secretary of the Party Committee of Peking University, read out the decision of commending doctoral students, and more than 500 doctoral students won this honor. In order to encourage doctoral students to engage in high-level scientific research and improve the quality of doctoral students’ training, since 2009, Peking University has established a doctoral student principal scholarship, which is the highest honor, the largest amount and the most influential postgraduate scholarship established in Peking University. Professor Hao Ping called on the students to follow the example of the commended students, study hard and concentrate on scientific research.

Principal Lin Jianhua: Learn to be an adult.

"Don’t imprison curiosity because of grades. Every course and every topic is an opportunity to explore the mysteries of nature and human beings." President Lin Jianhua said to the students, "I want to remind everyone not to be too utilitarian and short-sighted, and not to go with the flow;" Follow your heart and find your own interests. In fact, professionalism is hidden behind every major. "

He said that in order to encourage students to develop freely, Peking University supports the free transfer of majors within the department and the free selection of courses in the whole school. The interdisciplinary training plan also gives students a very broad choice, and the way of thinking and values are more important than knowledge. "Knowledge can be out of date, but the way of thinking, social responsibility and spirit of exploration that you feel will flow in your heart like blood and accompany you all your life."

Lin Jianhua mentioned that in the face of the rapid development of science and technology in today’s society, some people will wonder whether science and technology will shake the cornerstone of human society and human civilization. He quoted Apple CEO Cook’s speech at the MIT graduation ceremony: "I am not worried that artificial intelligence can give computers the ability to think like humans. I am more worried that humans think like computers."

"Our education is not about turning people into machines, but about learning to be human." Lin Jianhua said, "Learning is not to passively accept knowledge, but to form one’s own experiences and opinions through comparison, speculation, debate and practice, so as to truly grasp the law, seek the true meaning and establish socialist core values."

He said: "Learning to be an adult is also a process of discovering your own ignorance. Being brave in discovering and admitting your own ignorance is the real performance of self-confidence. Always keep an open mind, be brave in questioning and learn with an open mind. I hope that students can explore, think and listen in silence and experience the joy of growth and creation. "

For a long time, rational humanism in the west has always occupied a dominant position. Facing the challenges of globalization and resources and environment, Lin Jianhua believes that the concept of "all things are one, and heaven and man are one" in China’s traditional culture, as well as the benevolent way expressed by "don’t do to others what you don’t want them to do to you" and "stand up for others if you want to stand up, and achieve what you want", will provide a more solid ethical foundation for the development and progress of mankind.

President Lin Jianhua spoke at the ceremony.

Zhao Lanxin, a new student representative: Why shouldn’t teenagers dream of catching stars? Dare to shoot a jade scale with a mulberry bow

Zhao Lanxin is a 2017 undergraduate freshman from Yuanpei College of Peking University, and ranked fifth in science in Chongqing College Entrance Examination. She once won the first place in the Chinese Women’s Mathematical Olympiad and the gold medal in the all-China Mathematical Olympiad. The "mathematical genius" said in her speech that mathematics is certainly a fascinating road, which always echoes the flow of everything with concise laws, but she has a longer and tougher string in her heart, and writing is her inner passion.

"When I look around my world, I find that the world is moving rapidly. Ordinary people also have vivid joys, sorrows, loves and hates, and they are separated. Many people don’t care about these, but I have a sense of responsibility that must be recorded in my heart. What I hope is that I will write and leave a soft inscription for our times. "

"Peking University has the best mathematics major in China, and I can continue to explore the mysteries of human rationality. Peking University also has the best Chinese major in the world, so that I can use the pen and ink of interest and love to describe the world."

Different from the life ideals of most competition students, Zhao Lanxin doesn’t want to follow the ready-made model, but wants to choose a road she loves. Although she hasn’t won a gold medal in the field of literature, she has enough enthusiasm for literary creation from her heart. For her, "go out of her comfort zone and explore an unknown but desirable distance." Is the best way to realize your dreams and values. She also wishes everyone present can find and realize their dreams.

Finally, she ended her speech with a poem of her own, "Why don’t teenagers dream of reaching for stars?"? Dare to shoot the jade scale with a mulberry bow. Don’t be too smart today, and invite him to see the sea level tomorrow. "

Teacher Representative Sun Qixiang, Dean of Peking University Institute of Economics: Cherish.

"When youth dies, you lose your health without vitality, elegance and wisdom. Even if you are still young, what is the use of youth, wealth and time?" On behalf of the teacher, Sun Qixiang, Dean of Peking University Institute of Economics, warned the students to cherish their health and not to overdraw your body just because you are young. Students are required to be young people with all-round development in morality, intelligence and physique, and to balance the relationship between study and exercise.

When talking about the dream and desire of youth, Sun Qixiang said, "Please cherish your inner desire, and don’t ignore and suppress it, or even snuff it out, and do what you like, instead of following others’ advice and being impetuous. Don’t compare with others, it’s enough to be the best yourself. "

Combined with his study experience, Sun Qixiang said, "This era has given everyone a chance. However, any beautiful era did not come out of thin air, but was created by thousands of builders through hard work, and the best treasure is to make due contributions to this era. "

In addition, Sun Qixiang told the students to cherish the present, others, teachers and students, friends and parents’ efforts and hard work.

【President Lin Jianhua.Full text of speech】

Good morning, dear classmates!

In the most beautiful season in Beijing, Peking University welcomed the new students of 2017, and the youthful vitality filled the beautiful campus with joy. We often compare a university to a big family, in which students, teachers, employees and alumni are all important members. Whether you are new to Peking University or continuing your studies here, we are soul mates, simple and pure, and strive to move forward. Welcome! Welcome to join the big family of Peking University!

Looking at everyone’s youthful smiles, I think of the first time I came to Peking University. It has been forty years since. The past 40 years, like a realistic version of the travel drama, have changed so much that people can’t imagine.

Zhongguancun Street was called Baiyi Road at that time, which was a rural road, with thick and towering Populus tomentosa and rice fields on both sides full of rural interests. At that time, it was still a big thing to go to town. There was only one bus No.332, or a bicycle that was still a luxury was about to be borrowed.

Forty years have passed, and everything is changing, but one thing remains unchanged, that is, Peking University people’s feelings for home and country, their fearless spirit of being the first in the world and their unremitting academic pursuit.

What will happen in the future? What kind of world will you face? This may be a doubt in the hearts of many young people. The rapid development of science and technology has changed people’s way of life and work, and the rapid rise of China has changed the traditional world political structure. These things sound great and far away, but they have already happened to us.

Making students become people who can lead the future is the talent training goal of the school, and it is also a challenge to educational concepts and traditions. The school is carrying out undergraduate education reform and postgraduate training mechanism reform, with the aim of providing you with a better learning and growth experience.

Everyone will soon enter the first grade course. Some students will be very concerned about grades, but don’t imprison their curiosity. In fact, every course and topic will give you an opportunity to explore the mysteries of nature and human beings.

University is a journey of exploration, discovery and creation by teachers and students. Follow your curiosity and explore the way of thinking behind knowledge with innovative and critical eyes, and you will surely gain more.

People often say that "interest is the best teacher", and the free transfer of majors in the department, free course selection in the whole school and interdisciplinary training plans will provide you with broad choices.

I want to remind everyone not to be too utilitarian and short-sighted, and not to go with the flow; Follow your heart and find your own interests. In fact, there is a professional spirit behind every major. Knowledge can be out of date, but the way of thinking, social responsibility and spirit of exploration you feel will flow in your heart like blood and accompany you all your life.

As we all know, AlphaGO defeated the top human Go player and made a major breakthrough in gene editing technology. This makes some people worry that science and technology will shake the cornerstone of human society and human civilization. That’s not how I see it.

Apple CEO Cook put it very well. He said, "I’m not worried that artificial intelligence gives computers the ability to think like human beings. I’m more worried that human beings think like computers-abandon compassion and values and be reckless."

Our education is not to turn people into tools and machines, but to "learn to be adults".

There will be an important international conference in Peking University next year-the 24th World Philosophy Conference, with nearly 5,000 philosophers from all over the world attending, which will be a grand gathering where eastern and western civilizations collide and blend. The theme of the conference is "Learning to be human".

For a long time, rational humanism in the west has always occupied a dominant position. Facing the challenges of globalization and resources and environment, I believe that the concept of "all things are one, and heaven and man are one" in China’s traditional culture, as well as the benevolent way expressed by "don’t do to others what you don’t want them to do to you" and "stand up for others if you want to stand up, and achieve what you want", will provide a more solid ethical foundation for the development and progress of mankind.

"Learning to be an adult" is a proposition that accompanies us all our lives. Philosophy considers "learning to be an adult" from the theoretical level, while education is the practice of "learning to be an adult".

Learning is by no means a passive acceptance of knowledge, and you can’t swallow dates and follow others’ advice. Instead, you should form your own insights through comparison, speculation, debate and practice, so as to truly grasp the law, seek the true meaning and establish the core values of socialism.

General Secretary of the Supreme Leader said: "Active thinking is an important feature of colleges and universities, where various ideas and viewpoints meet and various values collide. Taishan does not let the soil, so it can become a big one; Rivers and seas do not choose small streams, so they can be deep. We must uphold the attitude of respecting differences and accommodating diversity, lead by pluralism and neutrality, seek consensus in diversity, set the direction in change, and let all the trickle of beneficial ideology and culture merge into the vast sea of mainstream ideology. "

"Learning to be an adult" is also a process of discovering your ignorance. In ancient Greece, there was a philosopher, Zhi Nuo, the father of paradox. Students once asked him, "Teacher, you are knowledgeable, why do you always question your own conclusions?" Zhi Nuo drew two circles and said, "The big circle is me and the small circle is you. If the area of the circle is the knowledge we have, the outside of the circle is unknown, and the circumference is the unknown we can contact. The more visible knowledge, the more unknown we contact. "

The courage to discover and admit your ignorance is a sign of true confidence. You are all excellent. I hope that you will not be afraid of problems and difficulties, be dogmatic and inflexible, and always keep an open mind, be brave in questioning and learn with an open mind.

German philosopher Garf once said: "The voice of conscience is silent, and it is hard to be heard in the hubbub." The same is true of learning, which requires us to forget the worldly customs and explore, think and listen in silence.

I wish you all can calm down, listen to the voice of learning and experience the joy of growth and creation during your time at Peking University.

Thank you!

　　CCTV News:On April 10th, the State Council Joint Prevention and Control Mechanism held a press conference. Ren Hongbin, Assistant Minister of Commerce, and Li Xinggan, Director of Foreign Trade Department, introduced relevant measures to stabilize foreign trade and answered questions from reporters.

　　Ren Hongbin, Assistant Minister of Commerce, said that since the beginning of this year, affected by the COVID-19 epidemic, the development of foreign trade has faced severe challenges that have not been seen for many years. According to customs statistics, from January to February, China’s import and export, export and import decreased by 9.6%, 15.9% and 2.4% respectively in terms of RMB.

　　At present, the situation of domestic epidemic prevention and control continues to improve, and foreign trade enterprises have resumed their work and production in an orderly manner. However, the global epidemic has accelerated its spread, which has brought great impact on the global economy and trade. Judging from the recent investigation of key provinces and cities, import and export chambers of commerce and key enterprises by the Ministry of Commerce, foreign trade enterprises generally face many problems such as cancellation or postponement of orders in hand, difficulty in signing new orders, and poor logistics and transportation.

　　In the face of the severe foreign trade situation, the State Council timely introduced policies and measures to stabilize foreign trade. On March 10th, the the State Council executive meeting deliberated and adopted measures such as improving export tax rebate, increasing foreign trade credit and increasing export credit insurance support. On April 7th, the executive meeting of the State Council once again launched a series of policies to stabilize foreign trade, such as setting up a comprehensive cross-border e-commerce test zone, supporting the development of processing trade, holding an online Canton Fair, etc., and made a policy "combination boxing" to try to stabilize the basic foreign trade.

　　[Governing Concern, Studying and Implementing the Spirit of the Sixth Plenary Session of the Eighteenth Central Committee]

　　Take compensation and resettlement fees by deceiving superiors and deluding subordinates; Falsely reporting exaggerated statistical data, affecting scientific decision-making; Report good news but not bad news, fool inspection and seek false political achievements … … Recently, the phenomenon of individual party member cadres practicing fraud and deceiving their superiors and deluding their subordinates in their work has been frequently exposed, which has aroused widespread concern and must be resolutely corrected.

　　Seeking truth from facts is the party’s fine tradition. "Falsification, false reporting and exaggeration" is a serious political problem and a very harmful corruption. The Guidelines on Political Life within the Party under the New Situation (hereinafter referred to as the Guidelines) deliberated and adopted by the Sixth Plenary Session of the 18th CPC Central Committee clearly pointed out: "Party organizations at all levels and all party member must be loyal and honest to the Party, be honest, do honest things, and be honest" and "oppose fraud, false reporting and exaggeration, and oppose concealing the truth and not reporting bad news". Party member cadres must strictly abide by it.

　　Falsification is a very harmful corruption.

　　On November 18, the Intermediate People’s Court of Xining City, Qinghai Province publicly pronounced the case of Li Zhi, former deputy director of the Standing Committee of the People’s Congress of Xinjiang Uygur Autonomous Region, and sentenced the defendant Li Zhi to 12 years in prison for accepting bribes and fined him RMB 1 million. The property obtained by Li Zhi’s bribery shall be recovered and turned over to the state treasury. Previously, in the notice published on the website of the Supervision Department of the Central Commission for Discipline Inspection on July 6, 2015, it was pointed out that "Li Zhi seriously violated discipline, falsified files, and concealed his real age from the organization" and "used his position to facilitate the selection and appointment of cadres, business operations, etc. Seek benefits for others, ask for and accept huge bribes".

　　"We should be soberly aware that fraud and bullying are not only a matter of style, but also very harmful corruption in many cases." Long Bing, an associate professor at the School of Marxism, Hunan University, said that in order to pursue political achievements or seek personal interests, a few party member cadres have deviated from the Party’s principle of seeking truth from facts, deceived organizations, deceived the masses and had a bad influence, and must be severely punished.

　　"I thought that by taking advantage of loopholes, I could get subsidies by muddle through. Now that I think about it, this kind of behavior of deceiving the masses, deceiving party organizations and gaining personal gain is really inappropriate. " Wu Yinkun, former deputy secretary of the Party branch of Huangdi Village, Suban Town, xinluo district, Longyan City, Fujian Province, said in an investigation. Wu Yinkun was kept in the party for one year because of illegal declaration of subsidy funds for renovation of dangerous houses.

　　In recent years, some localities and departments have made false reports on statistical data, used false data to compete for fame and gain profits, and have been investigated and punished. The National Audit Office once issued a notice saying that Yongfu County in Guilin, Guangxi falsely reported the number of starts and the number of completions in the renovation of dilapidated houses in rural areas. 1509 households actually started construction, and 1920 households were reported to have started construction; 834 households were actually completed and 1,500 households were reported to have been completed. At present, Yongfu County has investigated the responsibility of the relevant staff, and given disciplinary and political sanctions to the leaders in charge of the County Housing and Construction Bureau and the relevant township leaders.

　　According to reports, at the signing site of an investment promotion meeting in a province in northwest China, several projects that had already signed contracts were "performed" at the signing site again. "In recent years, it has become an open secret for some places to falsely report and exaggerate the data of investment promotion projects. This reflects the distorted view of political achievements of some leading cadres. " Peng Runjin, deputy director of the Political Science Teaching and Research Department of the Party School of Jiangxi Provincial Party Committee, said.

　　"It’s better to say what you can do than to show what you can say. At present, in some localities and units, the problem of reporting good news without reporting bad news is also quite prominent. Tell the superior unit about the achievements and good aspects, and make great efforts to render them, but ignore the problems and difficulties. Failure to investigate, punish, or even condone those who resort to fraud has further contributed to this false and deceptive wind. " Long Bing said.

　　In the final analysis, it is impure party spirit and incorrect style of work.

　　"Power is a public instrument for serving the people. No matter what position you are in, you should perform your duties with awe and sincerity. Falsification and bullying are, in the final analysis, impure party spirit and incorrect style of work, and they are disloyal and dishonest to the party. " Chen Liaomin, vice president of the Xihu District People’s Court in Hangzhou, Zhejiang, said.

　　Analyzing the causes of fraud and other phenomena, experts generally believe that, first, individual party member cadres have weakened their party spirit and indifferent sense of purpose, engaged in formalism in their work, made superficial articles, and even abused power for personal gain; Second, some places or units have the wrong orientation of selecting and employing people and unreasonable assessment system, which leads to individual party member cadres being good at "exaggerating" their achievements, being good at "covering up" their mistakes, or deceiving some unrealistic assessment indicators by fraud; Third, the supervision of power is weak and the punishment for violations of laws and regulations is not enough, which has not formed an effective deterrent.

　　Zheng Dai, a cadre of the Research Office of the Organization Department of Yiyang Municipal Committee of Hunan Province, believes that some leading cadres have bureaucratic style and do not go deep into the grassroots to conduct research. Even if they go on, they just listen to reports and look at materials. Even the research routes and interviewees have been arranged at different levels, making it difficult to understand the real situation. This gives fraudsters an opportunity.

　　"Whether you can seek truth from facts in your work tests whether the party spirit of party member cadres is firm." Sun Chengyao, a researcher in the Department of Teaching and Research of Party History and Party Construction at the Party School of Zhejiang Provincial Party Committee, said that party member cadres’ falsification, false reporting and exaggeration and one-sided pursuit of abnormal outlook on political achievements are putting the cart before the horse in serving the people and their personal reputation. They should start from their ideological roots, supplement their spiritual calcium and establish a realistic outlook on political achievements.

　　"Since the founding of New China, especially in the past 40 years of reform and opening-up, China has made remarkable development achievements, thanks to the loyalty and honesty of thousands of party member cadres in Qian Qian, who insist on being honest, telling the truth and doing honest things. Falsification and bullying have seriously affected the party’s image and the party’s career development. " Long Bing said.

　　Be honest, tell the truth, do honest things.

　　"Falsification not only affects the scientific decision-making of the party and the government, but also harms the interests of the people. It will also dampen the enthusiasm of party member cadres who are practical and destroy the political ecology within the party and must be severely corrected." Sun Chengyu said.

　　A correct view of power is like an inner law, which leads party member cadres to seek truth from facts and go straight on the right path. He Husheng, a professor at the School of Marxism of Renmin University of China, said that party member cadres should constantly improve their party spirit, strengthen their political determination, be loyal to the Party, consciously fight against unhealthy trends such as formalism and bureaucracy, and maintain the political nature of communist party people.

　　"To make being an honest man become party member’s pursuit, we should always tighten the string of loyalty to the party, take the initiative in the face of urgent and dangerous tasks, and keep the bottom line in trivial matters." In Zheng Dynasty’s view, it is not enough for party member to be honest, only by individual consciousness. It is also necessary to organize people who dare to show their swords to dishonest people and things, and resolutely curb the abnormal phenomenon of "honesty suffers".

　　He Husheng said that it is necessary to adhere to the correct orientation of selecting and employing people and select cadres who do practical things and do practical things. At the same time, the party’s political discipline should be strictly observed, and an institutional arrangement should be formed in which the power must be held accountable, the use of power must be held accountable, and the abuse of power must be held accountable. For some cadres who do not do practical things, they should strengthen supervision and accountability, increase punishment, continuously reduce the occurrence of fraud, and urge cadres to consciously tell the truth, do honest things, and be honest.

　　"Make full use of internet plus’s public supervision, broaden the channels for people’s supervision, let party cadres be tested in a wider social space, and let those cadres who practice fraud and make false reports have nowhere to hide." Peng Runjin said.

　　The General Secretary of the Supreme Leader pointed out: "To be honest is to be loyal and honest to the party, the people and comrades, to be honest, to be honest, to be honest, to be honest, to be fair and upright." The words are still ringing in our ears, and party member cadres must always keep them in mind.

Original porridge medical digestive liver disease channel included in the topic #2020 CGC18.

I’ve heard of many kinds of vaccines. Is there an Hp vaccine?

Speaking of Helicobacter pylori (Hp), I think everyone is familiar with it. Hp is a gram-negative spiral bacteria, which mainly spreads from person to person through oral route [1]. The infection rate of Hp in Chinese is very high, exceeding 50%, and the current research proves that Hp has an ambiguous relationship with gastric cancer, and the World Health Organization (WHO) has identified it as a grade I carcinogen of gastric cancer.

Traditional treatment has always relied mainly on acid inhibitors combined with antibiotics to eliminate Hp to treat related diseases caused by it, but the abuse of antibiotics has led to the rising drug resistance rate of Hp. So, can we eradicate Hp? I’ve heard of many kinds of vaccines. Is there an Hp vaccine?

At the just-concluded 20th National Academic Conference on Digestive Diseases of Chinese Medical Association, Professor Zou Quanming from the Biopharmaceutical Teaching and Research Section of the Department of Pharmacy of Army Military Medical University gave a wonderful report on the theme "How far is Hp vaccine from us?".

Do we need Hp vaccine?

First of all, Professor Zou Quanming raised a question: Do we need Hp vaccine?

▎Hp is closely related to gastric cancer and has serious harm.

At present, there are three different views on Hp in the medical field:

1. The pathogenicity of Hp is serious, and vaccine is needed for radical cure;

2. Hp is still helpful to the human body, even probiotics;

3. Hp and human beings have coexisted for a long time, and their existence is reasonable.

These different viewpoints have seriously affected the research and appearance of Hp vaccine.

According to the data released by the National Cancer Center in 2017, there are about 680,000 new cases of gastric cancer in China each year, accounting for nearly one-third of all cancers in China, accounting for about 50% of the total incidence in the world, and the mortality rate also accounts for about 50% of the world total. Hp infection can almost always cause active inflammation of gastric mucosa. On the basis of chronic inflammation, some patients can also develop a series of diseases such as peptic ulcer and gastric cancer (1%).

Hp infection has brought great disease burden and economic loss to people, but at present, people pay insufficient attention to Hp. Professor Zou Quanming emphasized that Hp is very harmful and we need Hp vaccine.

▎ At present, antibiotics are used to treat Hp, but the symptoms are not cured.

Traditional treatment has always relied mainly on acid inhibitors combined with antibiotics to eliminate Hp to treat related diseases, but antibiotics can only eliminate the existence of individual Hp or suppress its proliferation, and can not achieve the goal of eradicating Hp for the whole society. And the drug resistance caused by frequent use of antibiotics, such as clarithromycin and metronidazole, has become a serious problem in some countries. In addition, the use of antibacterial therapy to eradicate Hp is not sustainable. In some countries, the annual recurrence rate of Hp is as high as 15%-30%.

Professor Zou Quanming said that China, Japan, South Korea and other countries in the Far East, including many countries in Eastern Europe, have a high incidence of gastric cancer. Under the condition of extensive vaccination, even if the hidden Hp infection of patients is not detected, the incidence of gastric cancer can be reduced. In developed countries, it is calculated that a 10-year vaccination program can greatly reduce the prevalence of ulcer and gastric cancer caused by Hp, and also reduce the incidence of related diseases and economic losses.

Basic questions to be answered in Hp vaccine research

However, the research of Hp vaccine is not smooth sailing. Professor Zou Quanming pointed out that it is very difficult to study Hp vaccine and the following problems need to be solved:

1. Why is the immune response caused by natural infection of the host not protective?

2. What are the mechanisms and differences between immune protective response and pathological injury?

3. Screening and transformation of vaccine effective antigen?

In addition, the immune mechanism of Hp infection is very complicated.

Figure 1: Infection immune mechanism of 1：Hp

Research progress of preventive Hp vaccine

Next, Professor Zou Quanming introduced the research progress of Hp vaccine at home and abroad:

Figure 2: Research progress of Hp vaccine at home and abroad.

Professor Zou Quanming and his research team established the strategy of "intramolecular adjuvant mucosal vaccine of Hp", which has been verified by practice. This technique can produce sIgA antibody in gastrointestinal mucus (which is completely different from serum IgG antibody), thus blocking Hp infection.

Fig. 3: Mechanism of action of intramolecular adjuvant mucosal vaccine of 3：Hp.

Animal experiments show that the protective rate of the oral recombinant Hp vaccine in mice, rats and rhesus monkeys is more than 80%.

In addition, Professor Zou Quanming and his research team established an efficient system for screening components of Hp vaccine for the first time, and successfully constructed an engineering strain of Hp vaccine that can be used for production. More than 300 strains of Hp and more than 1,500 candidate protein components were collected from patients in 20 provinces and cities in China, and finally the Hp vaccine components were selected, and an efficient and stable vaccine purification process was established. The purity of the produced vaccine protein was over 80%, and the output was 400,000 mg/time (reaching the production scale).

In 2015, the clinical research results of "Oral Helicobacter pylori vaccine phase III" conducted by Professor Zou Quanming and his research team were published online in the top medical journal The Lancet.

Figure 4: The research results are published online in The Lancet.

In this study, more than 30 technical specifications, standards and experimental detection technologies necessary for human clinical trials of Hp vaccine I, II and III were established. And through the invention and creation of the above key technologies, more than 4,000 volunteers aged 6-15 have been developed and completed in phase I, II and III human clinical trials.

Figure 5: Distribution and shedding of subjects

Figure 6: Analysis results of infection prevention effect

The results showed that there were 64 cases of Hp infection during the follow-up period, that is, 14 cases were infected in the vaccine group (2025 people) and 51 cases were infected in the control group (2058 people). The total protection rate of oral recombinant Hp vaccine against infection was 71.8%.

In terms of safety, 157 (7%) people in the experimental group and 161 (7%) people in the control group had one or more adverse reactions during the study. Among them, 5 (< 1%) people in the experimental group and 7 (< 1%) people in the control group had serious adverse reactions, but they all thought it had nothing to do with vaccination [2].

This shows that oral recombinant Hp vaccine is "effective, safe and immunogenic" among children who are not infected with Hp, which can significantly reduce the incidence of Hp infection.

Professor Zou Quanming said that he also took the Hp vaccine at that time. Up to now, he has been tested for Hp once a year, and the results have been negative.

This study is the first phase III trial of Hp vaccine in the world. Professor Philip Sutton of Melbourne University in Australia made a special comment on this study: "The successful development of this vaccine has taken an important step towards preventing gastric cancer caused by Hp. This will rekindle human passion for this important topic, further encourage more investment, and promote continuous progress in this field through in-depth clinical trials. "

The Hp vaccine is still in the approval stage and has not been approved for marketing. At the scene, Professor Zou Quanming also expressed his expectation and called on academic organizations and Hp study groups to jointly promote the listing of Hp vaccine.

Reference source:

[1] Chinese Medical Association, et al. Guidelines for primary diagnosis and treatment of Helicobacter pylori infection (2019). Chinese Journal of General Practitioners .2020,5 (19) 5.

[2]Ming Zeng,Prof Xu-Hu Mao,et,al.Efficacy, Safety, and Immunogenicity of an Oral Recombinant Helicobacter pylori Vaccine in Children in China: A Randomized, Double-Blind, Placebo-Controlled, Phase 3 Trial.The Lancet.2015,6(30).

Review of this article

Professor Cao xiaocang

Chief physician, professor, master tutor of Tianjin Medical University General Hospital of Gastroenterology.

Member of Digestive Endoscopy Committee of Inflammatory Bowel Disease Group of Digestive Branch of Chinese Medical Association.

Vice Chairman of the Youth Committee of Behavioral Medicine Branch of Chinese Medical Association

Member of Clinical Epidemiology Collaboration Group of Digestive Branch of Chinese Medical Association.

Member of Inflammatory Bowel Disease Group, Committee of Gastroenterology Branch of China Medical Equipment Association.

Member of anorectal difficult disease Committee of inflammatory bowel disease Committee of anorectal physician branch of Chinese Medical Doctor Association

Member of Expert Committee of Inflammatory Bowel Disease, Gastroenterology Professional Committee, China Society of Integrated Traditional Chinese and Western Medicine.

Member of the Expert Committee of Inflammatory Bowel Disease of Beijing Medical Award Foundation.

Standing Committee of Inflammatory Bowel Disease Alliance of Wu Jieping Medical Foundation, Standing Committee of Intestinal Microecology Professional Committee

Standing Committee of the Committee of Stem Cell Engineering Technology Branch of China Biomedical Engineering Society

Vice Chairman of Inflammatory Bowel Disease Group of Gastroenterology Branch of Tianjin Medical Association

This article starts: medical digestive liver disease channel

Author: CGC report group porridge

Original title: Helicobacter pylori vaccine, how far is it from us? 》

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