Is astrology scientific? Find your constellation in the night sky.

  Astronomy around us

  No matter how much you know about astronomy, you probably know what your "constellation" is. At present, the International Astronomical Union accurately divides the whole day into 88 constellations, of which 12 are called the zodiac constellations and are associated with the date of birth. Do you know how your constellation is determined? And is it scientific to link the date of birth with the constellation and infer people’s fate?

  The zodiac determined by the sun

  Because the earth revolves around the sun once a year, we will see the sun walking through the sky full of stars, once a year, and again. In order to record the position of the planet in the starry sky, the Babylonians recorded the trajectory of the sun in the starry sky — — The ecliptic is divided into 12 segments, and according to the shape arrangement of some brighter planets in each segment, they are named by the images in myths and legends, namely, Aries, Taurus, Gemini and other twelve constellations, and each constellation is assigned a unique symbol. After that, when they observe the positions of Mercury, Venus, Mars, Jupiter and Saturn visible to the naked eye in the starry sky, they only need to record the time and the constellation symbols where the planets are.

  The way to divide people’s constellations according to their birthdays is similar. For example, you were born in early June and belong to Gemini, because in early June, the sun was just near Gemini, the zodiac sign.

  Apparent motion of stars determined by earth’s revolution and rotation

  However, it is not realistic to see the constellation you belong to on your birthday. For example, people born in early June are classified as Gemini, but really enjoying Gemini in the night sky will have to wait until winter.

  Maybe you have realized what the problem is. Because the sun shines brightly, the constellation where the sun is located is just covered by its light, so when the sun passes through which constellation, we just can’t see it at that time. To enjoy this constellation well, we can only wait for it to appear in the night sky after half a year away from the sun.

  Although stars and planets are at different distances from us, in the starry sky at night, they all seem to be on the same huge spherical shell. This imaginary ball is called the celestial sphere. Seen from the earth, the movement of the sun on the celestial sphere, that is, the apparent movement of the sun in the sky in astronomy, can be divided into two situations. One is that the sun rises in the east every morning, reaches the farthest position from the horizon at noon and sets in the west in the evening. This visual effect caused by the earth’s rotation from west to east is called Sunday apparent motion. The other is that in a year’s time, the sun passes through the constellations in the sky and finally returns to the starting point, which is called the annual visual movement. This is caused by the revolution of the earth.

  The sun’s Sunday apparent motion and annual apparent motion are superimposed, which causes the stars to rise and set in the west every night, but the stars that rise every day are different, and they also rotate once a year on the celestial sphere. The zodiac sign on the celestial sphere, which is with the sun, will be at the other end of the connection between the sun and the earth in half a year, hanging high above your head at midnight.

  Due to the shape of the earth itself and the gravitational effect of the sun and the moon on the earth, there is still a slow change in the direction of the earth’s rotation axis. The movement of the earth’s axis, called precession, is similar to that of a falling gyro. When the gyro itself is still rotating, the direction of the gyro axis is also circling. It takes about 26,000 years for the earth’s axis to rotate once, so it may be difficult to feel the existence of precession through the naked eye in a person’s life. However, thousands of years have passed since the Babylonians lived, and the effect of precession is highlighted: the actual position of the sun in the celestial sphere and the definition of the Babylonians have deviated from two constellations.

  Falsified astrology

  Although it is simple and easy to use constellations as a tool for astrometry, its accuracy is not high. With the development of astrometry technology, this method is no longer used in subsequent observation and research. However, this once scientific tool has been "carried forward" in the hands of others, and a set of complicated statements has been concocted, which link people’s personality, fate and other signs with constellations. Many people are convinced of these statements, and even use them as guiding ideology in matters that need to be taken seriously, such as personnel arrangement and finding a partner.

  In 1983, Sean Carlson, a scientist at the University of California, Berkeley, conducted a double-blind experiment in astrology, and published the results in Nature, a top international scientific magazine, in 1958. In the experiment, he invited the best astrology "experts" recommended by astrology circles in the United States, and fully communicated with these astrologers on the experimental methods and obtained their consent. In the first part of the experiment, the experimenter first collected the data of each subject according to the requirements of astrologers. After the astrologers predicted the personality characteristics of each subject according to these data, the experimenter provided each subject with three predictions without signature, one of which was made by the astrologer for the specific subject himself and the other two by the astrologer for other subjects. The subjects scored the degree of consistency between the three predictions and themselves. In the second part of the experiment, each subject obtained his own personality characteristics through the California Personality Scale (CPI). Each astrologer will get three unsigned test results, one for a specific subject and the other two randomly selected. Astrologers need to choose the questionnaire that belongs to that specific subject from these three copies. The test results show that the success rate of astrologers’ prediction is the same as the random probability. In layman’s terms, the success rate is basically the same as relying on "Meng".

  In other words, it is a good way to find out your own "constellation" according to your date of birth. But I hope to know my future and destiny, and that is modern superstition.

  (The author is a doctoral student at the National Space Science Center, Chinese Academy of Sciences)

  (The pictures in this edition are from the Internet except for labeling.)

In September, construction activities remained active, and investment showed a sustained and stable trend.

CCTV News:From the perspective of non-manufacturing industry, the business activity index of non-manufacturing industry in September released today (September 30) is still in the expansion range.

In September, China’s non-manufacturing business activity index was 50.6%, down 2 percentage points from the previous month. From the perspective of the industry, due to factors such as the epidemic situation, the market activity of the service industry weakened in September.

He Hui, Assistant President of China Federation of Logistics and Purchasing:However, online activities have remained relatively good, especially in the productive service industry, including postal activities.

In September, the postal business activity index and new order index related to online shopping increased by more than 5 percentage points month-on-month, which were higher than 60% and 58% respectively, indicating that residents’ willingness to shop online has increased.

In addition, the business activity index of the construction industry in September was 60.2%, up 3.7 percentage points from the previous month, hitting a new high in the year. The comprehensive index changes, driven by the continuous promotion of policies and the peak construction season, the construction industry activities remain active and the investment shows a sustained and stable trend.

Zhao Qinghe, Senior Statistician, Service Industry Survey Center, National Bureau of Statistics:The business activity index of the construction industry has rebounded sharply, and it has rebounded to a high boom zone, which shows that all localities have intensified their efforts to promote the implementation of infrastructure construction projects, thus driving the accelerated expansion of construction enterprises (production activities).

In addition, the business activity index of the financial industry rose to over 60% in September, rising for two consecutive months, indicating that the social financing foundation supporting investment and other industry activities is relatively stable.

General Administration of Customs: Allow the import of Russian wild aquatic products that meet relevant requirements.

CCTV News:According to the news released by the Customs on November 8, the General Administration of Customs issued an announcement that Russian wild aquatic products that meet the relevant requirements will be allowed to be imported from now on according to the laws and regulations of China and the requirements of the General Administration of Customs of the People’s Republic of China and the Russian Federation Veterinary and Phytosanitary Supervision Bureau on inspection and quarantine and veterinary hygiene of Russian wild aquatic products exported to China. I. Inspection and Quarantine Basis

  (1) People’s Republic of China (PRC) Entry-Exit Animal and Plant Quarantine Law, People’s Republic of China (PRC) Entry-Exit Animal and Plant Quarantine Law Implementation Regulations, People’s Republic of China (PRC) Import and Export Commodity Inspection Law Implementation Regulations of People’s Republic of China (PRC) Import and Export Commodity Inspection Law Implementation Regulations of People’s Republic of China (PRC) Food Safety Law and People’s Republic of China (PRC) Food Safety Law Implementation Regulations;

  (2) Measures for the Administration of Import and Export Food Safety in People’s Republic of China (PRC) and Regulations on the Registration of Overseas Production Enterprises of Imported Food in People’s Republic of China (PRC);

  (3) Protocol between the General Administration of Customs of the People’s Republic of China and the Veterinary and Phytosanitary Supervision Bureau of the Russian Federation on Inspection, Quarantine and Veterinary Hygiene Requirements for Russian Wild Aquatic Products Exported to China (hereinafter referred to as the Protocol).

  Second, the scope of imported products

  Wild aquatic products refer to wild aquatic biological resources for human consumption, that is, aquatic animal and plant products such as fish, aquatic invertebrates, aquatic mammals, algae, etc., excluding species, live aquatic animals and aquatic animal breeding materials listed in the appendix of the Convention on International Trade in Endangered Species of Wild Fauna and Flora (CITES) of March 3, 1973 and the national list of key protected wild animals in China.

  Third, the production enterprise requirements

  Production enterprises exporting wild aquatic products to China (including fishing boats, processing boats, transport boats, processing enterprises and independent cold storage) should meet the requirements of China and Russia’s relevant veterinary hygiene and public health regulations, and be approved by Russian officials and effectively supervised by them.

  According to the Food Safety Law of People’s Republic of China (PRC) and the Implementation Regulations of the Entry-Exit Animal and Plant Quarantine Law of People’s Republic of China (PRC), the production enterprises exporting wild aquatic products to China shall be recommended for registration by the Veterinary and Plant Health Supervision Bureau of the Russian Federation (hereinafter referred to as Russia) to the General Administration of Customs of the People’s Republic of China (hereinafter referred to as China). Without registration, it may not be exported to China.

  Iv. requirements for imported products

  Russia should ensure that wild aquatic products exported to China meet the following conditions:

  (1) Aquatic biological resources legally caught in the waters, territorial seas, continental shelf, convention areas and high seas of the Russian Federation.

  (two) raw materials and products are not in the following areas:

  1. Aquatic animal diseases related to Protocol products listed in the List of Quarantine Diseases of Entry Animals in People’s Republic of China (PRC) and required to be notified by the World Organization for Animal Health (WOAH) occurred in Russian territory, which made wild aquatic products exported to China infected or possibly infected;

  2. Any major food safety incident in Russia has affected or may affect wild aquatic products exported to China;

  3. The wild aquatic products that Russia has exported or intends to export to China seriously violate the laws and regulations of China and Russia and the provisions of the Protocol;

  4. Major public health events occur in production enterprises, such as employees infected with major infectious diseases, which have polluted or may pollute wild aquatic products exported to China and their packaging and transportation tools;

  5. The fishing area is affected by pollutants, such as radioactive pollutants, which have polluted or may pollute wild aquatic products exported to China.

  (3) Not directly or indirectly using drugs or additives prohibited by both parties; Using drugs or additives restricted or allowed by the Chinese side according to regulations; After inspection by the competent authorities, no pathogenic microorganisms, toxic and harmful substances and foreign bodies listed in China and Russian laws and regulations were found.

  (4) All wild aquatic products exported to China have passed the quarantine inspection by the competent Russian authorities, and are hygienic and safe for human consumption. No aquatic animal diseases listed in the List of Quarantine Diseases of Entry Animals in People’s Republic of China (PRC) and required to be notified by the World Organization for Animal Health (WOAH) have been found.

  (5) The whole process of fishing, processing, packaging, storage, transportation, transit and export shall meet the relevant hygiene requirements and traceability requirements of both parties. At the same time, it meets the relevant safety and hygiene requirements of cold chain food.

  V. Certificate requirements

  Every container of wild aquatic products exported from Russia to China should be accompanied by at least one original veterinary (health) certificate, which proves that this batch of products conforms to the veterinary and public health laws and regulations of China and Russia and the relevant provisions of the Protocol. The Russian side should fill in the information of production enterprises involved in the whole process of fishing, processing, packaging, storage, transportation, transit and export, including the names and registration numbers of fishing vessels, processing vessels, transport vessels, processing plants and independent cold storage on the veterinary certificate.

  The certificate is printed in Chinese, Russian and English (English is the required language when filling out the certificate). The format and content of the certificate must be approved by both parties in advance. The Russian side shall promptly provide the Chinese side with the sample certificate, official seal and handwriting style of the signing officer for the record. If there are any changes, the Russian side should file with the Chinese side at least one month before the entry into force.

  Six, packaging and labeling requirements

  Russian wild aquatic products exported to China should have outer packaging and separate inner packaging (except for further processing). Internal and external packaging should be brand-new materials that meet international hygiene standards and meet the requirements of preventing pollution from external factors.

  There should be firm, clear and legible labels in Chinese and English on the internal and external packages, including: trade name and scientific name, specifications, production date, shelf life, batch number, preservation conditions, production method (wild fishing), name and registration number of the production enterprise, production area, address of the production enterprise (specific to state/province/city) and destination (marked as People’s Republic of China (PRC)).

  For wild aquatic products exported to China in the form of pre-packaging, the pre-packaged Chinese label shall meet the label requirements of China imported from prepackaged foods.

  VII. Other requirements

  China Customs implements import inspection and quarantine on wild aquatic products exported to China.

  Non-conforming products will be returned, destroyed or otherwise disposed of in accordance with the laws and regulations of China. China will take measures such as strengthening inspection and quarantine or suspending imports for production enterprises that have serious problems or repeatedly failed to meet the requirements.

First-line experience in Spring Festival travel rush, Nanning, Guangxi: not afraid of "trouble" but "safety"

   Xinhua News Agency, Nanning, February 3rd Title: Not afraid of "trouble" but "safety" — — First-line knowledge of Spring Festival travel rush, Nanning, Guangxi

   Xinhua News Agency reporter Xiang Zhiqiang, He Wei, Qin Xingxing

   With the end of the Spring Festival holiday, under the situation of fully preventing and controlling the epidemic, how to ensure smooth and safe? The reporter visited the railway station, bus station, highway intersection and airport in Nanning, Guangxi, and found that the front-line staff in Spring Festival travel rush worked overtime to strictly prevent and control, and the passengers treated it rationally and actively cooperated with the inspection.

   Peak-shifting stability of passenger flow

   The reporter saw in the square in front of Nanning Railway Station that there were scattered passengers waiting to enter the station, which was very different from the scene of crowds surging in Spring Festival travel rush in previous years. "There are only eight or nine thousand passengers departing from Nanning Station every day in these two days." Lu Jinren, passenger transport director of Nanning Station, said.

   At Nanning Airport and Langdong Bus Station in Nanning, the passenger flow has been greatly reduced compared with previous years. Lang Xiaoling, the person in charge of Langdong Bus Station, said that in recent days, the daily passenger traffic has been more than 1,000, compared with more than 10,000 in the same period last year.

   According to the data of China Railway Nanning Bureau Group Co., Ltd., the railway passenger flow in Guangxi has decreased by about 70% year-on-year. According to the needs of epidemic prevention and control and passenger flow changes, as of January 31, Nanning Bureau Group has stopped 157 passenger trains. According to Nong Xiaoling, at present, inter-provincial passenger buses and some buses in Guangxi are out of service, and the number of passenger trains has dropped by about 70% compared with the same period last year.

   Compared with public transportation, the passenger flow returning by private car is relatively stable. At the exit of Nanning East Expressway, there is an endless stream of private cars entering the city, which is smooth and orderly. "Our family originally planned to take a train back to Nanning, but later, considering the large traffic on the train, we chose to drive a private car to return." Mr. Lin who returned to Nanning from Liuzhou said.

   At the same time, despite the delay of the Spring Festival holiday, many passengers have returned in advance due to many factors such as epidemic prevention and control, and there is no congestion of centralized return. The relevant staff of Nanning East Expressway exit told reporters that the peak of traffic flow appeared in the third, fourth and fifth days in recent days, and it has gradually decreased since the sixth day.

   Work overtime and weave a tight protective net.

   Chen Kang Zhuang, deputy secretary of the Party Committee of Nanning Railway Station, came to the security checkpoint in front of Nanning Railway Station Square early these two days to take the temperature of the passengers entering the station. "In order to strengthen the frontline manpower, from the afternoon of the second day of the New Year’s Day, more than 100 department cadres at the station have invested in the front line to carry out epidemic prevention and control." Chen Kangzhuang said.

   The reporter saw at Nanning Railway Station that there were staff at the entrance and exit to detect the temperature of passengers. Xie Qun, from the Eighth People’s Hospital of Nanning, said that the medical staff is on duty at the railway station 24 hours a day, and is responsible for the second test of passengers with high body temperature. If the temperature is confirmed to be too high, they will be sent to the fever clinic for further diagnosis and treatment.

   I will receive passenger consultation at the service desk for a while, receive key passengers at the platform for a while, and ask my colleagues to take care of the elevator … … In the railway station, passenger attendant Nong Xiujuan kept walking back and forth, and her mobile phone and walkie-talkie kept ringing. "In places like stations where people are densely populated and mobile, the prevention and control of the epidemic is to be meticulous and meticulous." Nong Xiujuan said.

   Nong Xiujuan has been holding on to the post of passenger transport for 26 years, and will retire in September this year. Colleagues affectionately call her "farmer’s mother". She is experienced and more confident.

   Nanning Airport has not only set up a number of infrared temperature measuring doors and artificial temperature measuring points, but also disinfected and cleaned the ground, equipment and tools in the public area and work area of the terminal building at least three times a day. It has also set up a number of mask recycling boxes in the terminal building to centrally recycle and prevent the abandoned masks from secondary pollution.

   At the epidemic prevention checkpoint of Nanning East Expressway, two passages and four groups of people kept checking passengers, and a four-person car could be tested in less than 10 seconds.

   "It’s very cold in the morning, I wear a lot of clothes, and there are protective clothes outside. It was very hot after noon, and I didn’t have time to change clothes after sweating. " Zhou Haifeng, a staff member on duty, said that they are currently implementing "three shifts".

   "The more detailed the inspection, the more assured I am."

   On the 1st morning, Wang Yuming took his wife and children from his father-in-law’s house in the countryside of Hengxian County, Nanning, and set foot on the journey back to Sichuan. In front of the county town, the highway intersection and the railway station square, they received three consecutive body temperature tests. "I am not afraid of trouble. The more detailed the inspection, the more assured I am." The reporter saw that, like the Wang Yuming family, almost all passengers wore masks and paid attention to protection.

   Chen Qiong Numa and Chen Xuefen, who are waiting at Nanning Airport, are preparing to fly to Fuzhou. "I went out to the airport from my hometown Zhoulu Town, mashan county in the morning, took a car, an airport bus and other means of transportation, and took my temperature four times." Chen Qiong Numa said that he was not worried about the safety of traveling by plane because everyone attached great importance to it and carefully tested it.

   At the epidemic prevention checkpoint not far from the exit of Nanning East Expressway, although vehicles need to wait in line for testing, the owners are very patient. Guo Wangjun, the car owner who just finished the test, said, "The epidemic situation is serious, so it is necessary to carry out epidemic prevention inspection. It doesn’t matter if you wait for a little time. It is most important to ensure safety." (Participating in reporter Lei Jiaxing)

Collection | A batch of museum online exhibition resources stay at home to watch the exhibition

  Original title: Culture | National Cultural Heritage Administration pushes a batch of online exhibition resources of national museums.

  Recently, under the deployment of National Cultural Heritage Administration, museums all over the country, while doing a good job in the prevention and control of pneumonia in novel coronavirus, have launched a number of wonderful online exhibitions by using existing digital resources, and combined with social forces to innovate communication methods to provide safe and convenient online services for the public, cheering for the fight against the epidemic, responding with practical actions and implementing the call of the CPC Central Committee the State Council to win the battle of epidemic prevention and control. In order to facilitate public inquiry and browsing, National Cultural Heritage Administration has summarized the online museum exhibitions produced in various places, and will publish relevant links on the website in batches.

  The first batch of sorted links are now published as follows:

  Summary of online museum exhibitions (the first batch)

  1. Greet the auspicious New Year-celebrate the New Year in the Forbidden City

  The Palace Museum

  https://www.dpm.org.cn/subject_hesui/guide.html

  2. Panoramic Palace Museum

  The Palace Museum

  http://webapp.vizen.cn/gugong_app_pc/index.html

  3. Return-Italian Return to China Lost Cultural Relics Exhibition

  National Museum of China

  https://webapp.vizen.cn/backhome/index.html

  4. Digital Exhibition Hall of Military Museum in Past Dynasties

  military museum of the chinese people’s revolution

  http://3d.jb.mil.cn/lidai/index.html

  5. Virtual tour of Gongwangfu Museum, Ministry of Culture and Tourism

  Gongwangfu Museum, Ministry of Culture and Tourism

  http://www.pgm.org.cn/vr/tmp002/#d3k

  6. Praise the Republic-Celebrate the 70th anniversary of the founding of New China’s scientific and technological achievements.

  China Science And Technology Museum

  https://xnmy.cdstm.cn/vr/70372/

  7. Home and Everything Prosperous-Theme Exhibition of Family Education Style

  China Women and Children Museum

  https://www.boyuntu.com/demo/zgfnet/web/pc.html

  8. Online Experience Hall of Capital Museum

  Capital museum

  http://www.capitalmuseum.org.cn/zlxx/wstyg.htm

  9. Home and Life

  Tianjin Museum of Natural History

  https://www.tjnhm.com/TianJinZiRanGuan/index.html

  10. The glory of the Warring States-the ancient Zhongshan State

  Hebei Museum

  http://webapp.vizen.cn/album_pano/v1.0.47/index.html? albumId=A0494D82F3EC436CB5F58CF7F89A3195&lang=&vrflag=on

  11. Gan Kun on the wall-Shanxi Northern Dynasties tomb mural art exhibition

  shanxi museum

  http://quanjing.artron.net/scene/ynpXBuG3QXSFKzwnqHBZ4tNQABCWMfOC/bishangqiankun/tour.html

  12. Digital Exhibition Hall of Inner Mongolia Natural Museum

  Inner Mongolia Natural Museum

  http://wechat.immnh.org.cn/wxnmg/virualvrs.html? from=singlemessage

  13. "Shengshi Collection-National Treasure Exhibition in Shenyang Palace Museum"

  Shenyang Palace Museum

  https://www.superhz.com/ty/SY360/ssdc2/tour.html

  14. Digital display of the memorial hall of the First Congress of the Communist Party of China

  Memorial Hall of the First Congress of the Communist Party of China

  http://www.zgyd1921.com/zgyd/n4/n75/n76/ulai532.html

  15. Nantong Museum Basic Exhibition Virtual Exhibition

  Nantong museum

  http://www.ntmuseum.com/view/view_cl1/index.html

  16. Nanjing Massacre Historical Exhibition

  The Memorial of the Nanjing Massacre

  http://www.19371213.com.cn/exhibition/njdtsssz/

  17. Yangzhou Museum Digital Museum

  Yangzhou Museum

  http://3vking.com/yangbo/vtour/tour.html

  18. Source and flow: Nanjing in 99 cultural relics

  Nanjing museum head office

  http://beyond.3dnest.cn/play/? m=90685696_VZS6_b6f9&from=singlemessage

  19. Reality Suzhou Museum

  Suzhou Museum

  http://webapp.vizen.cn/museum_pano_app_pc/index.html? appId=5998

  20. Digital display of Nanhu Revolutionary Memorial Hall

  Nanhu revolution memorial hall

  https://baike.baidu.com/item/%E5%8D%97%E6%B9%96%E9%9D%A9%E5%91%BD%E7%BA%AA%E5%BF%B5%E9%A6%86/4544827? fr=aladdin

  21. Special Exhibition "Lucid waters and lush mountains are invaluable assets-Practice of Ecological Civilization from Yucun"

  Zhejiang Natural Museum

  http://www.zmnh.cn/lintezhan/lintezhan-info.html? category=18&id=25346

  22. Exhibition of the quintessence of Wu Yuechu’s cultural relics in the Yue Dynasty.

  Zhejiang Provincial Museum

  https://www.zjmuex.com/Exhibition/DExhibitionDetails/SZZL? nid=550

  23. Beacon Jianghuai-Anhui Revolutionary History Exhibition

  anhui museum

  http://cms.ahm.cn/hzgj/userfiles/2019/8/21/1566371226203/

  24. Red Minxi

  Central Soviet Area (Minxi) History Museum

  https://720yun.com/t/b8vkiqdwzpl? from=singlemessage

  25. The People’s Republic is coming from here-the history of chinese soviet republic

  Ruijin Central Revolutionary Base Memorial Hall

  https://720yun.com/t/z4mno4yx2li58gaesr

  26. The Central Red Army assembled in the capital and set out for the basic exhibition of the Long March.

  yudu county museum

  http://www.hongsehui.cn/service/venue/667/

  27. Great Discoveries —— Nanchang Exhibition of Archaeological Achievements of the Sea Faint Hou State in Han Dynasty

  Jiangxi museum

  http://www.jxmuseum.cn/xnbz/html/xnbz.html

  28. Great Confucius Exhibition

  Confucius Museum

  http://quanjing.artron.net/scene/LfTt638kxEFs4xlBfwgaw4SpmZLZndt8/kozhibowuguanchangshezhan/tour.html? from=singlemessage

  29. Qingzhou History Exhibition, the first state in the East of America.

  Qingzhou Museum

  https://vr.ejudata.com/static/play.html? projectId=58aa49b9d75b0e000fcdb267&from=singlemessage

  30. People call for Jiao Yulu.

  henan museum

  http://www.chnmus.net/template/viewCatalogList? catalogId=8115945c775d4a9ca891ec6c47bedbd0&pubPlat=PC

  31. The development history of China characters.

  Chinese Character Museum

  http://www.wzbwg.com/Szzb

  32. Red Memory-the Central Committee of the Communist Party of China is in Wuhan

  Wuhan the Central Committee of the Communist Party of China organ former site memorial hall

  https://720yun.com/t/c6e2fuOkwl6? pano_id=1672669

  33. Digital Exhibition Hall of the Communist Party of China (CPC) Discipline Construction History Exhibition Hall

  the wuhan revolutionary museum

  http://www.lzg.whgmbwg.com/pano/

  34. Cloud Exhibition of Xinhai Revolution Museum

  Xinhai Revolution Museum

  https://sosomap.cn/api/view/pano/xhgmbwg

  35. Shiyan Museum Virtual Exhibition Hall

  Shiyan Museums

  http://u.eqxiu.com/s/BI4amxUp? share_level=1&from_user=2020020130479e1c&from_id=306dfefe-e&share_time=1580519170646&from=singlemessage

  36. Hunan people-Sanxiang historical and cultural exhibition

  Hunan Provincial Museum

  http://www.hnmuseum.com/sites/default/files/statics/museum_exhibition/src/indexpc.html? albumid=494216DC23684425BBB9AAACE471A6B1

  37. Learn from Lei Feng’s good example

  Lei feng memorial, Hunan

  https://720yun.com/t/acvkiwdegqb

  38. There is an online exhibition hall of Mao Zedong in China.

  Shaoshan Mao Zedong Memorial Museum

  http://www.txssw.com/jngclzl/XuNiZhanTin/museum/index.html

  39. Three-dimensional panoramic view of Nanyue King Museum in Western Han Dynasty.

  Museum of the Western Han Dynasty Mausoleum of the Nanyue King

  https://www.gznywmuseum.org/XiHanNanYueWang_20171107/release/index.html

  40. Guangzhou 1949

  guangdong museum of revolutionary history

  https://720yun.com/t/41vkihqq58q? scene_id=36722459

  41. Chongqing Hongyan Revolutionary History Museum Virtual Exhibition

  Chongqing Hongyan Revolutionary History Museum

  http://112.74.61.33:7999/CQHY/CQHY_20180417/web/choseexhibit.html

  42. The Life of "Guoqiang" —— Exhibition of Physical Evidence of Chongqing’s Life Changes to Celebrate the 70th Anniversary of the Founding of New China.

  chongqing china three gorges museum

  http://www.3gmuseum.cn/data/ziyuan/virtual/web/seventieth-anniversary/tour.html

  43. Discovery of Sanxingdui: Sanxingdui and Bashu Archaeology

  sanxingdui museum

  http://quanjing.artron.net/scene/3PI8cyI6kXE18EXHXWK76JgBwPitFrBJ/sxd/tour.html

  44. Ingenious craftsmanship: the modern rebirth of traditional crafts.

  Chengdu Museum

  http://cdm360.cdmuseum.com/cdmu/statictour/cdmu/8fh87vu09z337o1/index.html

  45. Shaanxi ancient civilization

  Shaanxi History Museum

  http://www.qinling360.com/sxlsbwgxin/yiting/

  46. Panoramic Terracotta Warriors and Horses

  emperor qinshihuangs mausoleum site park

  http://39.104.142.130/html/public/zl/500yvr/bc726d2972a949c180c4f85216e6c5ea.html

  47. Exquisite Exhibition of Unearthed Cultural Relics from Hanyang Mausoleum in Cheng Kang, Yinchang of the Empire.

  Han Jingdi Yangling Museum

  https://720yun.com/t/wzpng6p95q0n7geesq? from=singlemessage&isappinstalled=0&pano_id=kt4bZcch6orv828s

  48. Gansu Silk Road Civilization

  Gansu Provincial Museum

  http://www.gansumuseum.com/xncg/flash_sczl/index.html

  49. Digital Dunhuang Exhibition "Dunhuang Art Walking Out of Mogao Grottoes"

  Dunhuang Academy

  http://public.dha.ac.cn/quanjing/shuzidunhuang/tour.html

  50. Memories of the history of the Western Regions

  Xinjiang Uygur Autonomous Region Museum

  https://720yun.com/t/fdvkuw8mspe

  Content source: National Cultural Heritage Administration WeChat WeChat official account

Be loyal to the party, be honest and not cheat.

  [Governing Concern, Studying and Implementing the Spirit of the Sixth Plenary Session of the Eighteenth Central Committee]

  Take compensation and resettlement fees by deceiving superiors and deluding subordinates; Falsely reporting exaggerated statistical data, affecting scientific decision-making; Report good news but not bad news, fool inspection and seek false political achievements … … Recently, the phenomenon of individual party member cadres practicing fraud and deceiving their superiors and deluding their subordinates in their work has been frequently exposed, which has aroused widespread concern and must be resolutely corrected.

  Seeking truth from facts is the party’s fine tradition. "Falsification, false reporting and exaggeration" is a serious political problem and a very harmful corruption. The Guidelines on Political Life within the Party under the New Situation (hereinafter referred to as the Guidelines) deliberated and adopted by the Sixth Plenary Session of the 18th CPC Central Committee clearly pointed out: "Party organizations at all levels and all party member must be loyal and honest to the Party, be honest, do honest things, and be honest" and "oppose fraud, false reporting and exaggeration, and oppose concealing the truth and not reporting bad news". Party member cadres must strictly abide by it.

  Falsification is a very harmful corruption.

  On November 18, the Intermediate People’s Court of Xining City, Qinghai Province publicly pronounced the case of Li Zhi, former deputy director of the Standing Committee of the People’s Congress of Xinjiang Uygur Autonomous Region, and sentenced the defendant Li Zhi to 12 years in prison for accepting bribes and fined him RMB 1 million. The property obtained by Li Zhi’s bribery shall be recovered and turned over to the state treasury. Previously, in the notice published on the website of the Supervision Department of the Central Commission for Discipline Inspection on July 6, 2015, it was pointed out that "Li Zhi seriously violated discipline, falsified files, and concealed his real age from the organization" and "used his position to facilitate the selection and appointment of cadres, business operations, etc. Seek benefits for others, ask for and accept huge bribes".

  "We should be soberly aware that fraud and bullying are not only a matter of style, but also very harmful corruption in many cases." Long Bing, an associate professor at the School of Marxism, Hunan University, said that in order to pursue political achievements or seek personal interests, a few party member cadres have deviated from the Party’s principle of seeking truth from facts, deceived organizations, deceived the masses and had a bad influence, and must be severely punished.

  "I thought that by taking advantage of loopholes, I could get subsidies by muddle through. Now that I think about it, this kind of behavior of deceiving the masses, deceiving party organizations and gaining personal gain is really inappropriate. " Wu Yinkun, former deputy secretary of the Party branch of Huangdi Village, Suban Town, xinluo district, Longyan City, Fujian Province, said in an investigation. Wu Yinkun was kept in the party for one year because of illegal declaration of subsidy funds for renovation of dangerous houses.

  In recent years, some localities and departments have made false reports on statistical data, used false data to compete for fame and gain profits, and have been investigated and punished. The National Audit Office once issued a notice saying that Yongfu County in Guilin, Guangxi falsely reported the number of starts and the number of completions in the renovation of dilapidated houses in rural areas. 1509 households actually started construction, and 1920 households were reported to have started construction; 834 households were actually completed and 1,500 households were reported to have been completed. At present, Yongfu County has investigated the responsibility of the relevant staff, and given disciplinary and political sanctions to the leaders in charge of the County Housing and Construction Bureau and the relevant township leaders.

  According to reports, at the signing site of an investment promotion meeting in a province in northwest China, several projects that had already signed contracts were "performed" at the signing site again. "In recent years, it has become an open secret for some places to falsely report and exaggerate the data of investment promotion projects. This reflects the distorted view of political achievements of some leading cadres. " Peng Runjin, deputy director of the Political Science Teaching and Research Department of the Party School of Jiangxi Provincial Party Committee, said.

  "It’s better to say what you can do than to show what you can say. At present, in some localities and units, the problem of reporting good news without reporting bad news is also quite prominent. Tell the superior unit about the achievements and good aspects, and make great efforts to render them, but ignore the problems and difficulties. Failure to investigate, punish, or even condone those who resort to fraud has further contributed to this false and deceptive wind. " Long Bing said.

  In the final analysis, it is impure party spirit and incorrect style of work.

  "Power is a public instrument for serving the people. No matter what position you are in, you should perform your duties with awe and sincerity. Falsification and bullying are, in the final analysis, impure party spirit and incorrect style of work, and they are disloyal and dishonest to the party. " Chen Liaomin, vice president of the Xihu District People’s Court in Hangzhou, Zhejiang, said.

  Analyzing the causes of fraud and other phenomena, experts generally believe that, first, individual party member cadres have weakened their party spirit and indifferent sense of purpose, engaged in formalism in their work, made superficial articles, and even abused power for personal gain; Second, some places or units have the wrong orientation of selecting and employing people and unreasonable assessment system, which leads to individual party member cadres being good at "exaggerating" their achievements, being good at "covering up" their mistakes, or deceiving some unrealistic assessment indicators by fraud; Third, the supervision of power is weak and the punishment for violations of laws and regulations is not enough, which has not formed an effective deterrent.

  Zheng Dai, a cadre of the Research Office of the Organization Department of Yiyang Municipal Committee of Hunan Province, believes that some leading cadres have bureaucratic style and do not go deep into the grassroots to conduct research. Even if they go on, they just listen to reports and look at materials. Even the research routes and interviewees have been arranged at different levels, making it difficult to understand the real situation. This gives fraudsters an opportunity.

  "Whether you can seek truth from facts in your work tests whether the party spirit of party member cadres is firm." Sun Chengyao, a researcher in the Department of Teaching and Research of Party History and Party Construction at the Party School of Zhejiang Provincial Party Committee, said that party member cadres’ falsification, false reporting and exaggeration and one-sided pursuit of abnormal outlook on political achievements are putting the cart before the horse in serving the people and their personal reputation. They should start from their ideological roots, supplement their spiritual calcium and establish a realistic outlook on political achievements.

  "Since the founding of New China, especially in the past 40 years of reform and opening-up, China has made remarkable development achievements, thanks to the loyalty and honesty of thousands of party member cadres in Qian Qian, who insist on being honest, telling the truth and doing honest things. Falsification and bullying have seriously affected the party’s image and the party’s career development. " Long Bing said.

  Be honest, tell the truth, do honest things.

  "Falsification not only affects the scientific decision-making of the party and the government, but also harms the interests of the people. It will also dampen the enthusiasm of party member cadres who are practical and destroy the political ecology within the party and must be severely corrected." Sun Chengyu said.

  A correct view of power is like an inner law, which leads party member cadres to seek truth from facts and go straight on the right path. He Husheng, a professor at the School of Marxism of Renmin University of China, said that party member cadres should constantly improve their party spirit, strengthen their political determination, be loyal to the Party, consciously fight against unhealthy trends such as formalism and bureaucracy, and maintain the political nature of communist party people.

  "To make being an honest man become party member’s pursuit, we should always tighten the string of loyalty to the party, take the initiative in the face of urgent and dangerous tasks, and keep the bottom line in trivial matters." In Zheng Dynasty’s view, it is not enough for party member to be honest, only by individual consciousness. It is also necessary to organize people who dare to show their swords to dishonest people and things, and resolutely curb the abnormal phenomenon of "honesty suffers".

  He Husheng said that it is necessary to adhere to the correct orientation of selecting and employing people and select cadres who do practical things and do practical things. At the same time, the party’s political discipline should be strictly observed, and an institutional arrangement should be formed in which the power must be held accountable, the use of power must be held accountable, and the abuse of power must be held accountable. For some cadres who do not do practical things, they should strengthen supervision and accountability, increase punishment, continuously reduce the occurrence of fraud, and urge cadres to consciously tell the truth, do honest things, and be honest.

  "Make full use of internet plus’s public supervision, broaden the channels for people’s supervision, let party cadres be tested in a wider social space, and let those cadres who practice fraud and make false reports have nowhere to hide." Peng Runjin said.

  The General Secretary of the Supreme Leader pointed out: "To be honest is to be loyal and honest to the party, the people and comrades, to be honest, to be honest, to be honest, to be honest, to be fair and upright." The words are still ringing in our ears, and party member cadres must always keep them in mind.

AI lip service driving these black technologies shine the light of the internet Expo.

  International Online Report (Reporter Zhang Silu Deng Chenxi): On December 3rd, the 4th world internet conference opened in Wuzhen, Zhejiang Province. After the opening ceremony, the reporter walked into the 4th world internet conference Internet Light Expo and got a glimpse of this year’s black technology.

  It is understood that this year’s Expo has set up functional sections such as development concept area, comprehensive exhibition area, theme exhibition area, new product and technology release area and project cooperation and negotiation area, attracting 411 well-known domestic and foreign enterprises from all over the world to participate. During the conference, 118 new products and technologies will be released and 10 special matchmaking meetings on Internet project cooperation will be held.

  Dunhuang murals come alive; The official customizes exclusive memories for you; Learn to "change your face" in one second; AI helps you see a doctor for diagnosis; Move your lips to control the car … … The novel "black technology" of large and small enterprises at home and abroad appeared in this year’s Expo, focusing on the latest achievements of global Internet technology and application innovation and digital economy development such as cloud computing, Internet of Things and artificial intelligence.

National Cultural Heritage Administration made his debut at the Internet Conference.

National Cultural Heritage Administration made his debut at the Internet Conference.

  "internet plus Chinese Civilization" National Cultural Heritage Administration "Let Cultural Relics Live"

  This year, National Cultural Heritage Administration participated in the Light of the Internet Expo for the first time, and National Cultural Heritage Administration vividly presented the latest achievements of the deep integration of the Internet and Chinese civilization in recent years by combining objects, videos and interactive systems. Visitors can enjoy the exquisite Dunhuang murals and the precious collection of the Forbidden City at close range through a high-definition big screen, as if they were there.

VR automobile health examination

  VR automobile health examination

  Exclusive memories China Post customizes postcards for you.

  At the China Post booth, a device called "LOMO Time Machine" attracted many people’s attention. Sweep the phone, send a photo, print, and a few simple operations, and a postcard of your own can be made on the spot by DIY. Printed postcards can also be mailed on the spot.

  The booth also shows the latest welcome robot, MengMeng’s expression, funny dance and humorous interaction. Are you looking forward to seeing this little robot from MengMeng in the postal business hall?

Intelligent inquiry robot

Intelligent inquiry robot

  How to register? The intelligent guiding robot will tell you.

  At the Iflytek booth, the intelligent medical guidance robot "Xiao Yi" is serving the "patients". Iflytek’s artificial intelligence medical guidance robot "Xiao Yi" can automatically perform voice recognition, provide navigation, medical guidance, consultation and other services for patients, support various interactive modes such as sound and image, and reduce the repetitive consultation work of medical guidance personnel.

  According to the on-site staff, this intelligent medical guidance robot has been successfully applied in Anhui Provincial Hospital.

Sogou booth for human-computer interaction Pk

Sogou booth for human-computer interaction Pk

  Sogou — — You can drive a car by moving your lips.

  Do you have to be voice-activated to communicate with artificial intelligence? The black technology in sogou booth broke this convention, and everything can be manipulated by moving your lips. The Chinese lip recognition system in sogou booth attracted a large number of visitors to stop and experience.

  Chinese lip language recognition system is a kind of instruction issued by users by recognizing the movements of human lips in noisy environment. The reporter experienced the lip recognition function in the car environment, and the test results were very accurate.

Face changing game experience

Face changing game experience

  Learn the magic of "changing face" in one second

  Looking at the mirror in front of the screen, my face is magically covered with a delicate face. What kind of high technology is this? At the Tencent Film Festival, the reporter experienced a one-second "face change". According to the on-site staff, the technology uses filters and face recognition again. Therefore, as long as the user turns his head, the face recognition technology can change the face of people. In the future, such high-tech technology will be applied to interactive games.

Jin Qiaoqiao denied that the president’s husband secretly met Jiang Shuying! Once let half the entertainment circle celebrate her birthday, Princess Peacock is a real lady outside the show!

Friends, we are really tired of eating melons.Zhang Xiaohan, who is not very reliable, has drawn cartoons again!

This time, she still rushed to the hot search with ambiguous melons. According to her description, a "first-line intellectual actress" who is famous for her urban drama met with a married rich man in a hotel in Hainan, and the rich man also sent the actress high-luxury jewelry worth tens of millions to make her happy …

Regardless of whether this melon is real or not, who will take care of Zhang Xiaohan! Put it directly with a hammer. Stop drawing cartoons! Few of the comic books she drew before have ever come true …

But this netizen is right. People’s curiosity can’t be suppressed. Although we scold Zhang Xiaohan for having no credibility, we still can’t help but look for an "intellectual actress" who can sit in the right place according to the information disclosed.

Some netizens have even started to list the names of qualified actresses, such as Jiang Shuying, Dilraba, Angel, Chen Shu, Song Jia Jr., Sunny, Chen Douling, Wu Jinyan … The appraisal criteria are based on the paparazzi’s phrase "an intellectual actress who is famous for her urban drama".

Among them, Jiang Shuying was listed as the most likely actress by netizens because of too many details.

First of all, Jiang Shuying was really helped by the fire in Nothing But Thirty, and she did play a lot of urban dramas herself. It can be said that when I saw her face, I couldn’t help but think of urban female roles such as Jiang Lai and Wang Manni.

Recently, in Ode to Joy 3, Jiang Shuying still plays an urban white-collar Ye Zhenzhen.

Secondly, Jiang Shuying really went to Hainan recently and had a beautiful photo. In the photo, she has long hair, and the red flower in her ear seems to echo the red flower on the plate in Zhang Xiaohan’s cartoon.

As it happens, Jiang Shuying has also sent several selfies recently, and the jewels in the selfie are particularly eye-catching. Immediately, some netizens said: "Is this the jewelry sent by a wealthy businessman, so it is the show of love?"

However, some netizens immediately clarified that they searched for the same model in Jiang Shuying’s selfie. The bracelets and watches are more expensive, but as an actress in Jiang Shuying’s coffee spot, she can afford them. The necklace is only a niche brand with more than 1,000 pieces, which can’t reach the level of "ten million yuan jewelry" at all.

Jiang Shuying and his studio also denied this speechless rumor., the tone is full of helplessness:"I can be talked about, but I can’t be framed."

Then netizens found out that,The characters of wealthy businessmen and wives in cartoons seem to be very similar to those of Yu Dong, president of Bona Film, and his wife Jin Qiaoqiao., just Jin Qiaoqiao also dyed red hair.

After reading the so-called "evidence" dug up by these netizens, my little sister is completely speechless, and everyone’s ability to learn from the melon is really getting better and better!

Then Jin Qiaoqiao sent a message to respond to this matter:"Rumors stop at the wise! Watch more movies when you have time. "

Later, Jin Qiaoqiao replied to the comments of netizens in the comment area. In the face of the "persuasion" of netizens, my sister said that she was too speechless:"Can you don’t believe those false news that are fabricated and maliciously slandered on the Internet! It’s all fake! Fake! Fake! " "This netizen? Can you have a little brain? "

There are even netizens who call Jin Qiaoqiao the "little three" of Yu Dong, and Jin Qiaoqiao is so angry that he directly returns.: "Who are you talking about? Spread rumors? ! If you don’t get it, you have to take a lawsuit! "

Here, my little sister wants to get a word in,Jin Qiaoqiao clarified the "mistress" as early as 2014.Yu Dong ended his first marriage in 2010, and he and Jin Qiaoqiao only met in 2012, so there is no such thing as "mistress intervening".

Then Jin Qiaoqiao called Zhang Xiaohan, saying that he was also curious about who the three people in his cartoon were, and had to say that Jin Qiaoqiao was somewhat domineering!

Speaking of Jin Qiaoqiao, I believe that everyone’s first impression of her is stillThe charming and charming peacock princess in the 98 edition of The Journey to the WestOk! It is this role that opened her up.The road of "princess professional household".

The second princess in the East China Sea in "Pig Eight Rings in Spring" is also unforgettable, and Jin Qiaoqiao’s delicate, expensive and sweet appearance is really very suitable for playing the princess.

Princess Yuzhen in "The Secret History of Yang Guifei" is even more compassionate. Some netizens even commented that she is very "Guanyin" and has a kind face and a beautiful face.

Because of her extraordinary and recognizable beauty, Jin Qiaoqiao has been quite successful in her career since she graduated from Nortel, which is enough for most students to envy.

It is said that you can’t have both career and peach blossom, but Jin Qiaoqiao is different, and her peach blossom has never been bad.

No, Jin Qiaoqiao’s first love was vigorous enough. He directly held hands with Wu Qihua, the top student of TVB at that time, and officially announced his love affair. If this were put in today, it would be enough to paralyze the server.

At that time, Jin Qiaoqiao was quite pure and beautiful, and her figure was full of pure desire. She was a little girl with a happy face. Look at this dress, it is not out of date now!

Although Jin Qiaoqiao’s mother thinks that Wu Qihua and Jin Qiaoqiao are too different in age and somewhat introverted, she thinks that her daughter will not be happy to live with him.

But when the two were in the thick of love, they couldn’t listen to their parents’ thoughts at all.Wu Qihua even bought a mansion in Shanghai and gave it to Jin Qiaoqiao in the name of "wedding room"It is said that it cost 1.6 million, which was 1.6 million in 2003.

The good times didn’t last long, and the two finally broke up.After all, Wu Qihua is a "playboy" with too much romantic history, and it is really difficult to get results in falling in love with him.

Later, Jin Qiaoqiao has been caught in various scandals, but there has been no "positive fate".

For example, Jin Qiaoqiao, the unspoken rule of Zhang Guoli, was also caught by Deng Jie (although it seems that there is no real hammer at all now, it is just an empty talk and a visual sense) ↓

Some netizens broke the news that they had picked up Jin Qiaoqiao’s mobile phone, saying that Jin Qiaoqiao had received an ambiguous text message from a wealthy businessman who wanted to pay for her dinner date. The text message boasted:"We are not short of money, what price, Miss Jin can say. Whatever you want, we will never make a counter-offer. "

It’s not a scandal, can only say that the entertainment circle at that time was really in hot water …

Jin Qiaoqiao’s second love affair was with Yu Dong, CEO of Bona Film, and they went straight to the marriage hall. Jin Qiaoqiao also gave birth to a son and a daughter for Yu Dong.

I mean, I’m really principled, and I don’t talk much about love, either talking about being popular or talking about movie mogul.

After marrying the president, Jin Qiaoqiao is almost in a state of retirement. She has been working as a full-time mother at home, and her personal social accounts also record anecdotes about her children’s growth, and only occasionally does Yu Dong appear.

Netizens are deeply touched by this.In the past, the goddess became a child nanny after marrying into a rich family, or was she a "widowed baby"!

E-mail flipped through Jin Qiaoqiao’s account and found that there were not many children’s fathers.

Either take your children out with your parents ↓

Or take two dolls to the playground by yourself.

Recently, however, some netizens ran into Jin Qiaoqiao and Yu Dong to take the children to Universal Studios. My son took his mother’s hand and Yu Dong touched his son’s head while listening to the voice. The picture was quite warm. It seems that they were very happy, and netizens were also worried about it.

Although Jin Qiaoqiao has been a stay-at-home housewife for many years, it seems that her life is empty and her career is barren, but at least she is also a serious "Bona boss".

It’s up to her to hold a birthday party, and almost half of the big coffee in the entertainment circle came to celebrate her birthday., Jason Wu, Iola, Jet Li, Tung shing Yee, Xiang Huaqiang, Xiangtai, Zhang Ziyi, Li Xiang, Chiu Man-Cheuk, Pu Cunxin, Fan Ming, Fu Disheng, Ren Jing, Chen Xiao, Huang Yi, Tan Jing, Chen Xuedong … How many female stars can do this in-plane entertainment?

Jin Qiaoqiao had nothing to do but open a hot pot restaurant to kill time. Stars such as Yao Chen, Jerry Lee and Lin Yongjian rushed to call her new store, and her contacts were quite amazing.

Perhaps the family can also be a woman’s career. Although Jin Qiaoqiao has been away from the entertainment circle for many years, who said that it is not a real skill to run the family well? (text/seedling bag)

In this paper, the triple differentiation of mesenchymal stem cells (MSC) and its culture Protocol are summarized.

Mesenchymal Stem Cell (MSC) have unique biological characteristics and therapeutic potential, and are becoming a "new star" in the field of disease research, and the research enthusiasm continues unabated. MSC involves many related researches, such as multiple sclerosis, arthritis, neuropathic pain, intestinal diseases, etc., and is a research hotspot in the field of transplantation and autoimmune diseases.

Statistics on the number of published papers in MSC field from 2014 to 2024, with data from Pubmed.

Mesenchymal stem cells (MSC) are pluripotent stem cells derived from mesoderm with high self-renewal and multi-lineage differentiation potential. They are widely distributed in various tissues of the whole body, with the advantages of easy separation and easy acquisition, and can be differentiated and expanded in vitro.

MSC is an excellent tool for tumor therapy and gene transfer research, functional genomics, drug screening, Qualcomm screening and toxicology. International Association for Cell Therapy (ISCT) defines human MSC as:

Under standard culture conditions, it is adherent growth;

CD105, CD73 and CD90 should be expressed, but CD45, CD34, CD14 or CD11b, CD79α or CD19 and HLA-DR surface markers should not be expressed.

It can differentiate into osteoblasts, chondrocytes and adipocytes in vitro.

Mesenchymal stem cells come from a variety of cells or tissues, such as bone marrow, adipose tissue, peripheral blood, placental tissue, dental pulp and so on. Similarly, MSC can also differentiate into many cell types, such as osteoblasts, chondrocytes, fat cells, muscle cells, nerve cells, stromal cells and so on.

The origin and differentiation of MSC (from references)

It is worth noting that the differentiation potential of mesenchymal stem cells may vary with the source of stem cells, expansion conditions and their culture microenvironment. Three-line differentiation is the focus of MSC culture and amplification. Triple differentiation usually refers to osteogenesis, adipogenesis and chondrogenesis. In order to better understand the triple differentiation of MSC, this paper preliminarily summarizes the general process of triple differentiation of MSC and the identification methods corresponding to some markers.

Osteogenic differentiation

MSC can directionally differentiate into osteoblasts under the stimulation of various cytokines and other physical and chemical environments. Then the osteoblasts further differentiated into osteoblast precursor cells and entered a rapid proliferation period. Osteoblasts synthesize and secrete organic matrix at this stage, forming osteoid (mainly type I collagen), characterized by alkaline phosphatase, which is an early sign of osteoblast differentiation and maturity; Alkaline phosphatase appears blue under the microscope after fixation with blue, while undifferentiated cells have no obvious color.

Mature osteoblasts express ECM calcification-related proteins. Long-term osteogenic induction causes calcium ions to precipitate in the form of calcium salts, forming "bone nodules". Bone nodules can be dyed deep red by alizarin red (alizarin red reacts with calcium to produce a deep red compound), and the strength of osteogenic differentiation can be expressed by the area and depth of the pigment.

Identification of osteogenic differentiation of MSC from different sources

Chondrogenic differentiation

Firstly, MSC gathers into a cluster, and the middle cells in the cluster are transformed into a large and round cell, that is, chondrocyte, through division and differentiation. Chondrocytes produce matrix and fibers (mainly type II collagen), and the expression of type II collagen was observed by immunohistochemistry.

Generally, the differentiation results of chondrocytes were identified by Alyssin Blue. Alisine blue is an alkaline dye, which can combine with nucleic acid in cells to make the nucleus dark blue. At the same time, alisin blue combined with polysaccharides in cartilage matrix, making cartilage cells and matrix light blue.

Identification of chondrogenic differentiation of MSC from different sources

Adipogenic differentiation

There are two stages of adipogenic differentiation of MSC: first, it differentiates into adipose precursor cells, and then it differentiates into adipocytes under the influence of specific stimuli (such as C/EBPs and PPAR-γ).

Cells keep accumulating fat droplets in the cytoplasm and getting bigger. After dyeing with oil red O, it is red under the microscope. Undifferentiated cells have no obvious color.

Identification of chondrogenic differentiation of MSC from different sources

Various factors will affect the differentiation potential. Such as culture environment, growth factors and the existence of other cells, will affect the differentiation process. Specific signal molecules, such as bone morphogenetic protein (BMP) or Wingless related integration site (Wnt), can promote the differentiation of stem cells into bone cells or nerve cells, respectively.

The research on mesenchymal stem cells is so hot that Yiqiao Shenzhou has compiled a detailed MSC operation guide. Protocol is full of dry goods, in addition to the above three-line differentiation identification examples, it also includes how to isolate mesenchymal stem cells, how to subculture and expand them, and how to determine that the expanded cells are mesenchymal stem cells. Welcome to download and learn!

Click on the link above to download the Protocol.

References:

Dragomirka Jovic. A Brief Overview of Global Trends in MSC-Based Cell Therapy. Stem Cell Reviews and Reports, 2022. https://doi.org/10.1007/s12015-022-10369-1

Xing Liang Fan, et al. Mechanisms underlying the protective effects of mesenchymal stem cell-based therapy. Cellular and Molecular Life Sciences, 2020. https://doi.org/10.1007/s00018-020-03454-6

Yu Han, et al. Mesenchymal Stem Cells for Regenerative Medicine. Cells, 2019. doi:10.3390/cells8080886

Tilotta V, et al. Mesenchymal stem cell-derived secretome enhances nucleus pulposus cell metabolism and modulates extracellular matrix gene expression in vitro. Front. Bioeng. Biotechnol. 2023. doi: 10.3389/fbioe.2023.1152207

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How to listen to songs together with soda music How to listen to songs together with soda music [Detailed explanation]

  How do soda music listen to songs together? Soda music is an easy-to-use software for listening to songs. Users can customize the process of listening to songs when using it, and they can also listen to songs with friends. This small series has prepared a detailed tutorial for everyone, hoping to be helpful to your friends.

  1. First, turn on the soda music, and click "Three Points" in the lower right corner of the song in the recommendation.

  2. Then click the "Download" button in the upper left corner.

  3. After downloading, go to "My" and enter the "Download" interface.

  4. Then find the song to share and click "Three Points" on the right.

  5. Then select "Share" in the pop-up menu.

  6. Finally, just choose the object we want to share.

  The above is the relevant information brought by Xiaobian. Do you think you can help yourself deal with these problems? Like friends, come to IT Encyclopedia to watch more content.