Quadruple vaccine+domestic IPV, it is getting more and more fragrant.

I know some good news recently, and Dr. Tao wants to share it with you quickly. A definitive conclusion based on these good news is:

Quadruple (DTP +Hib) vaccine+domestic inactivated polio vaccine (IPV)

The price/performance ratio is getting higher and higher. It smells good.

Since 2002, Dr. Tao has collected all kinds of domestic vaccine products, coded and photographed them, and unconsciously built the China Vaccine Museum.

This vaccine museum is located in the vaccine science popularization base in Kangtai, Shenzhen. Crucially, Dr. Tao is still tirelessly collecting new vaccine products to contribute to this museum.

Vaccine Museum at No.18 Shutianpu Road, Shenzhen

Not long ago, Dr. Tao just collected the third domestic IPV from Kexing Bio. The first two paragraphs are from Institute of Medical Biology (Academia Sinica) and Beijing Beishengyan Biological Products Co., Ltd. (Beishengyan). In this way, with the import of IPV from Pasteur, there are four IPV models in China.

I accidentally compared the instructions of four IPV companies and made my first major discovery. However, we need to popularize the common sense of polio vaccine first.

The polioviruses used in two domestic IPV come from live oral vaccines. The vaccine virus in oral live vaccine is also called sabin strain virus, so domestic IPV is also called Sabin IPV(sIPV). The polio virus in Pasteur IPV comes from wild virus, also known as WIPV.

Before sIPV came out in China, the single inactivated polio vaccine was all wIPV. However, the use of wild viruses in wIPV production requires the highest biosafety level in vaccine workshops, and the possibility of polio epidemic caused by leakage into the environment cannot be ruled out.

IPV is a good thing, and China also wants to replace the oral live vaccine with major defects for all children (see:The way to avoid the devil’s lottery and vaccinate polio safely）。 However, China has a large population, and IPV is many times more expensive than oral live vaccine. If IPV can be localized, it will be much easier.

Just do it. Academia Sinica, which produces oral polio live vaccine (known as "sugar pill" vaccine), took the lead. In order to reduce the construction cost and biosafety risk, they found another way to directly inactivate the virus in the live vaccine to make IPV, and sIPV was born in the world. Beishengyan and Kexing Bio have reached the next level, and domestic sIPV imports wIPV three to one PK.

However, whether wIPV is better or sIPV is a difficult question to answer at first, but with the two IPvs used in China for 10 years, some data began to surface or be confirmed.

At first, Dr. Tao thought that although the virus sources were different, there was no substantial difference between them, and even they were winners and losers. But this time, after carefully reading the instructions of the three companies, I found a common phenomenon:The antibody levels of three sIPV in clinical trials are much higher than those of wIPV.I’m a little embarrassed that I didn’t notice this before.

See the table below for specific data. The third dose of basic immunity refers to one dose at 2, 3 and 4 months old, and the first dose of additional immunity refers to the fourth dose at 18 months old. Fourteen months after the third dose of basic immunization refers to the blood sampling test before the fourth dose.

For three types of poliovirus, the antibody levels of three domestic sIPV were higher than those of imported wIPV as control group at any time point, and the antibody level of type I virus was more obvious. The number of observers in these clinical trials is about 300 ~ 600, and the sample size is large enough to be an error.

Dr. Tao can say with certainty that the short-term immune effect of domestic sIPV is better than that of imported wIPV. Of course, the immune effect and protective effect are not the same thing. In fact, imported wIPV has been used outside China for more than half a century, and there is no evidence that its protective effect is unreliable, so there is no need to abandon wIPV.

This week, Dr. Tao saw that the Chinese Academy of Sciences published the 10-year observation results of sIPV and wIPV in eClinicalMedicine, a sub-journal of The Lancet, which was the final word.

10-year observation results https://t.cn/A6OENJOH

It can be seen that after 10 years, the antibody level of sIPV is also higher than that of wIPV. Inferred from this trend, the high probability will be the same after 20 years, at most, it will be flat, and it is impossible for the antibody level of sIPV to be lower than that of wIPV.

There is no doubt that sIPV’s immune effect is better than wIPV’s in both short and long term.

The above is the good news that Dr. Tao wants to share with you.

In order to prevent polio, diphtheria, pertussis, tetanus and Haemophilus influenzae (Hib) infection, every child should be vaccinated with three kinds of vaccines: polio vaccine, DTP vaccine and Hib vaccine.

There are many permutations and combinations of these three vaccines, and Dr. Tao once recommended using five vaccines directly. However, the cost performance of this scheme has dropped a lot, and the cost performance of [quadruple vaccine+domestic IPV] scheme is getting higher and higher because of the following two reasons:

First, four doses of polio vaccine are required, and the government can provide two doses of domestic IPV free of charge.

If you use pentavaccine, you can’t enjoy this free policy, because the price of pentavaccine includes imported IPV. Enjoy 2 doses of free domestic IPV, at least you can save 540 yuan. In 2023, the supply prices of five vaccines and four vaccines are 638 yuan and 368 yuan respectively, which is different from 270 yuan. Multiplying two doses is 540 yuan.

In the future, all 4 doses of polio vaccine will definitely be changed to 4 doses of free domestic IPV, and then 1080 yuan can be saved, which will be too fragrant.

Second, the five-vaccine is wIPV, which is not as fragrant as sIPV. The evidence is conclusive.

Of course, the five-vaccine also has an advantage at present, that is, it can be vaccinated at the age of 2 months, one month earlier than the four-vaccine, and protected earlier. Therefore, you can also choose five vaccines at the age of 2 months, and then choose all [four vaccines+domestic IPV].

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